Clinical Efficacy of Hybrid of Ampicillin and Sultamicillin: A Review

Authors

  • Babita Patial Assistant Professor, School of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA.
  • Poonam Dogra Assistant Professor, School of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA.
  • Sanjay Kumar Dean cum Principal, School of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA.
  • Mohit Sharma Student, School of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA.
  • Anil Kumar Student, School of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA.

Keywords:

ampicillin/sulbactam, Combine therapy, treatments, Clinical trials

Abstract

Emergence of lactamase-mediated resistance to β-lactam antibiotics among respiratory infections threatens the utilisation of clinically effective and well-tolerated lactam medicines. This article reassesses the clinical utility of ampicillin in conjunction with the β- lactamase inhibitor sulbactam in treating upper and lower respiratory tract infections. Clinical trials and meta-analyses show that ampicillin/sulbactam and sultamicillin are efficacious and well-tolerated in adults and children.

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References

• KumarR., SahaP., KahwaI., BoatengE. A., BoatengP. O., & NyarkoR. O. (2022). Biological Mode of Action of Phospholipase A and the Signalling and Pro and Anti Inflammatory Cytokines: A Review. Journal of Advances in Medicine and Medical Research, 34(9), 1-10. https://doi.org/10.9734/jammr/2022/v34i931342

• Awuchi, C. G., Amagwula, I. O., Priya, P., Kumar, R., Yezdani, U., & Khan, M. G. (2020). Aflatoxins in foods and feeds: A review on health implications, detection, and control. Bull. Environ. Pharmacol. Life Sci, 9, 149-155.

• Umama, Y., Venkatajah, G., Shourabh, R., Kumar, R., Verma, A., Kumar, A., & Gayoor, M. K. (2019). Topic-The scenario of pharmaceuticals and development of microwave as; sisted extraction technique. World J Pharm Pharm Sci, 8(7), 1260-1271.

• Roshan, K. (2020). Priya damwani, Shivam kumar, Adarsh suman, Suthar Usha. An overview on health benefits and risk factor associated with coffee. International Journal Research and Analytical Review, 7(2), 237-249.

• Kumar, R., Saha, P., Lokare, P., Datta, K., Selvakumar, P., & Chourasia, A. (2022). A Systemic Review of Ocimum sanctum (Tulsi): Morphological Characteristics, Phytoconstituents and Therapeutic Applications. International Journal for Research in Applied Sciences and Biotechnology, 9(2), 221-226.

• Sahana, S. (2020). Purabi saha, Roshan kumar, Pradipta das, Indranil Chatterjee, Prasit Roy, Sk Abdur Rahamat. A Review of the 2019 Corona virus (COVID-19) World Journal of Pharmacy and Pharmaceutical science, 9(9), 2367-2381.

• Alpuche-Aranda CM: Beta-lactamaseproductionandtherole of ampicillin/sulbactam.Pediatr Infect Dis J 1998;17: S8–S11.

• DajaniAS:Sulbactam/ampicillininpaediatricinfections.Drugs1988;35(Suppl7):35–38.

• DajaniAS:Ampicillin-sulbactam.PediatrAnn ;22:197–200

• Rubino CM, Gal P, Ransom JL: A review of thepharmacokineticandpharmacodynamiccharacteristicsofbeta-lactam/beta-lactamaseinhibitor combination antibiotics in prematureinfants.PediatrInfectDisJ1998;17:1200–1210.

• Raymond J, Aujard Y: Nosocomial infections inpediatricpatients:aEuropean,multicenterprospective study. Infect Control Hosp Epidemiol2000;21:260–263.

• FelminghamD,WashingtonJ:Trendsintheantimicrobialsusceptibilityofbacterialrespiratorytractpathogens–findingsoftheAlexanderProject1992–1996.JChemother1999;11(Suppl1):5–21.

• Raillard P, Feiner C, Ott V: Worldwide pediatricexperiencewithlow-dosesultamicillinoralsuspension.Curr Ther Res1994;55:601–613.

• Williams J: Beta-lactamases and beta-lactamaseinhibitors.IntJAntimicrobAgents1999;12:S3–S7.

• Bind, A., Das, S., Singh, V. D., Kumar, R., Chourasia, A., & Saha, P. Natural Bioactives For The Potential Management Of Gastric Ulceration. Turkish Journal of Physiotherapy and Rehabilitation, 32(3).

• Dubey, A., Yadav, P., Verma, P., & Kumar, R. (2022). Investigation of Proapoptotic Potential of Ipomoea carnea Leaf Extract on Breast Cancer Cell Line. Journal of Drug Delivery and Therapeutics, 12(1), 51-55.

• Saha, P., Kumar, R., Nyarko, R. O., Kahwa, I., & Owusu, P. (2021). HERBAL SECONDARY METABOLITE FOR GASTRO-PROTECTIVE ULCER ACTIVITY WITH API STRUCTURES.

• Sahana, S., Kumar, R., Nag, S., Paul, R., Chatterjee, I., & Guha, N. (2020). A REVIEW ON ALZHEIMER DISEASE AND FUTURE PROSPECTS.

• Sahana, S. (2020). Roshan kumar, Sourav nag, Reshmi paul, Nilayan guha, Indranil Chatterjee. A Review on Alzheimer disease and future prospects. World Journal of Pharmacy and Pharmaceutical science, 9(9), 1276-1285.

• Kumar, R., & Dubey, A. PHYTOCHEMICAL INVESTICATION AND HEPTOPROTECTIVE EVALUTION ACACIA RUBICA EXTRACT ISONIZED AND PARACETAMOL INDUSED ANIMAL TOXICITY. Turkish Journal of Physiotherapy and Rehabilitation, 32(3).

• Campoli-RichardsDM,BrogdenRN:Sulbactam/ampicillin.Areviewofitsanti-bacterial activity, pharmacokinetic properties,andtherapeuticuse.Drugs1987;33:577–609.

• FinegoldSM:Invitroefficacyofbeta-lactam/beta-lactamase inhibitor combinationsagainst bacteria involved in mixed infections.IntJAntimicrobAgents1999;12:S9–S14.

• MurrayPR,CantrellHF,LankfordRB:Multicenter evaluation of the in vitro activity ofpiperacillin-tazobactam compared with elevenselectedbeta-lactamantibioticsandcipro-floxacinagainstmorethan42,000aerobicgram-positiveandgram-negativebacteria.DiagnMicrobiolInfectDis1994;19:111–120.

• Baron EJ, Jones RN: National survey of the invitro spectrum of piperacillin-tazobactam testedagainstmorethan40 000aerobicclinicalisolatesfrom236medicalcenters.DiagnMicrobiol InfectDis1995;21:141–151.

• MurrayPR, Jones RN, Allen SD, Erwin ME, FuchsPC,GerlachEH:Multilaboratoryevaluation of the in vitro activity of 13 beta-lactam antibiotics against 1474 clinical isolatesofaerobicandanaerobicbacteria.DiagnMicrobiol InfectDis1993;16:191–203.

• FouldsG:Pharmacokineticsofsulbactam/ampicillin in humans: a review. Rev Infect Dis1986;8:S503–S511.

• Singh, M. K., Kumar, A., Kumar, R., Kumar, P. S., Selvakumar, P., & Chourasia, A. (2022). Effects of Repeated Deep Frying on Refractive Index and Peroxide Value of Selected Vegetable Oils. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 28-31.

• Nyarko, R. O., Kumar, R., Sharma, S., Chourasia, A., Roy, A., & Saha, P. (2022). ANTIBACTERIAL ACTIVITY OF HERBAL PLANT-TINOSPORA CORDIFOLIA AND CATHARNTHUS ROSEUS.

• Nyarko, R. O., Prakash, A., Kumar, N., Saha, P., & Kumar, R. (2021). Tuberculosis a globalized disease. Asian Journal of Pharmaceutical Research and Development, 9(1), 198-201.

• Raj, A., Tyagi, S., Kumar, R., Dubey, A., & Hourasia, A. C. (2021). Effect of isoproterenol and thyroxine in herbal drug used as cardiac hypertrophy. Journal of Cardiovascular Disease Research, 204-217.

• Nyarko, R. O., Boateng, E., Kahwa, I., & Boateng, P. O. (2020). A comparison analysis on remdesivir, favipiravir, hydroxychloroquine, chloroquine and azithromycin in the treatment of corona virus disease 2019 (COVID-19)-A Review. World J. Pharm. Pharm. Sci, 9, 121-133.

• Nyarko, R. O., Boateng, E., Kahwa, I., Boateng, P. O., & Asare, B. (2020). The impact on public health and economy using lockdown as a tool against COVID-19 pandemic in Africa: a perspective. J Epidemiol Public Health Rev, 5(3).

• Nyarko, R. O., Saha, P., Kumar, R., Kahwa, I., Boateng, E. A., Boateng, P. O., ... & Bertram, A. (2021). Role of Cytokines and Vaccines in Break through COVID 19 Infections. Journal of Pharmaceutical Research International, 33, 2544-2549.

• PURABISAHA, R. K., RAWAT, S. S. N., & PRAKASH, A. (2021). A REVIEW ON NOVEL DRUG DELIVERY SYSTEM.

• Kumar, R., Saha, P., Pathak, P., Mukherjee, R., Kumar, A., & Arya, R. K. EVOLUTION OF TOLBUTAMIDE IN THE TREATMENT OF DIABETES MELLITUS. Jour. of Med. P’ceutical & Alli. Sci, 9.

• FouldsG,McBride TJ, Knirsch AK, RodriguezWJ,KhanWN:Penetrationofsulbactamandampicillininto cerebrospinal fluid of infantsand young children with meningitis. AntimicrobAgentsChemother1987;31:1703–1705.

• SchaadUB,GueninK,StraehlP:Single-dosepharmacokineticsofintravenoussulbactamin pediatric patients. Rev Infect Dis 1986; 8: S512–S517

• VashiVI,SwansonRN, SwansonRN,Messig MA, Chung M: Pharmacokineticsofampicillinandsulbactaminpediatricpatients.AntimicrobAgentsChemother1999;43: 1225–1229.

• Sutton AM, Turner TL, Cockburn F, McAllisterTA: Pharmacokinetic study of sulbactam andampicillinadministeredconcomitantlybyintraarterialorintravenousinfusioninthenewborn.Rev Infect Dis1986;8:S518–S522.

• Komissarov IA: Pharmacokinetics of ampicillininacuteappendicitisinchildren.Vestn Khir1978;120:97–100.

• GinsburgCM,McCrackenGH,Jr,OlsenK,Petruska M: Pharmacokinetics and bactericidalactivityofsultamicillinininfantsandchildren.JAntimicrobChemother1985;15:345–351.

• Lode H, Hampel B, Bruckner G, Koeppe P: Thepharmacokinetics of sultamicillin. APMIS Suppl1989;5:17–22.

• MeierH,SpringskleeM,WildfeuerA:Penetrationofampicillinandsulbactamintohumancostalcartilage.Infection1994;22152–155.

• VoelkerMS,NightingaleCH,QuintilianiR,LehmannWB,KlimekJJ,HickingbothamJM:Sultamicillinuseinotitis media: penetrationof sulbactam, a beta-lactamase inhibitor, andampicillinintomiddle-earfluid.CurrTherapeuticRes1985;38:738–745.

• Lopez EL, Rivas NA: Clinical use of sultamicillin(ampicillin/sulbactam) in children. PediatrInfectDisJ1998;17:S12–S14.

• HuangLM,LeeCY,LeeMJ,HsuCY,Liu,CC,HongJY,etal:Aclinicalevaluationofsulbactam/ampicillininthetreatmentofpediatric infections. Chung Hua Min Kuo HsiaoErhKo I Hsueh Hui TsaChih1989;30:87–93.

• M, et al: Intravenous sulbactam/ampicillin inthetreatmentofpediatricinfections.DiagnMicrobiolInfect Dis1989;12:179S–183S.

• ScholzH,HeidlM,RockstrohT:Sulbactam/ampicillininchildrenwithbacterialinfections.ZacAAntimikrobAntineoplastChemother1986;4:89–94.

• ScholzH, Marker X, RockstrohT: Treatment ofbacterialinfectionsinchildrenwithsultamicillin.Int J Antimicrob Agents1996; 6:S41–S45.

• KanraG,SecmeerG,AkalinE,EcevitZ,CalikogluAS,GunelM,etal:Sulbactam/ampicillininthetreatmentofpediatric infections. Diagn Microbiol Infect Dis1989;12:185S–187S.

• MbondaE,DresseF,GeubelleF:Evaluationofhe efficacy and safety of parenteral sulbactam-ampicillinfollowedbyoralsultamicillinforpaediatric infections. Acta Therapeutica 1992;18:301–306.

• Kumar, R., Jain, A., Tripathi, A. K., & Tyagi, S. (2021, January). Covid-19 outbreak: An epidemic analysis using time series prediction model. In 2021 11th international conference on cloud computing, data science & engineering (Confluence) (pp. 1090-1094). IEEE.

• KUMAR, R., SAHA, P., SARKAR, S., RAWAT, N., & PRAKASH, A. (2021). A REVIEW ON NOVEL DRUG DELIVERY SYSTEM. IJRAR-International Journal of Research and Analytical Reviews (IJRAR), 8(1), 183-199.

• Kumar, R., Saha, P., Kumar, Y., Sahana, S., Dubey, A., & Prakash, O. (2020). A Review on Diabetes Mellitus: Type1 & Type2. World Journal of Pharmacy and Pharmaceutical Sciences, 9(10), 838-850.

• KUMAR, A. (2019). The Scenario of Pharmaceuticals and Development of Microwave Assisted Extraction Techniques.

• Saha, P., Nyarko, R. O., Lokare, P., Kahwa, I., Boateng, P. O., & Asum, C. (2022). Effect of Covid-19 in Management of Lung Cancer Disease: A Review. Asian Journal of Pharmaceutical Research and Development, 10(3), 58-64.

• Daharia, A., Jaiswal, V. K., Royal, K. P., Sharma, H., Joginath, A. K., Kumar, R., & Saha, P. (2022). A Comparative review on ginger and garlic with their pharmacological Action. Asian Journal of Pharmaceutical Research and Development, 10(3), 65-69.

• SHAFQAT ZAIDI, R. K. MEHRA, Dr. SACHIN TYAGI, ROSHAN KUMAR ANUBHAV DUBEY.(2021). Effect of Kalahari Cactus Extract on Appetitte, Body Weight And Lipid Profile In Cafeteria Diet Induced Obesity In Experimental Animal. Annals of the Romanian Society for Cell Biology, 25(6), 13976-13987.

• Kumar, R., & Saha, P. (2022). A Review on Artificial Intelligence and Machine Learning to Improve Cancer Management and Drug Discovery. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 149-156.

• Biolcati AH: An open comparative study of theefficacyandsafetyofsultamicillinversuscefaclor in the treatment of acute otitis mediain children. J Int Med Res 1992; 20 (Suppl 1):31A–43A.

• Chan KH, Bluestone CD, Tan LS, Reisinger KS,BlatterMM,FallPA:Comparativestudyofsultamicillinandamoxicillin-clavulanate:treatment of acute otitis media. Pediatr InfectDis J1993;12:24–28.

• AronoffSC,KlingerJD,O’BrienCA,JaffeAC,BlumerJL:Adouble-blindedcomparativestudyof sultamicillin and potassium penicillin V inthetreatmentofchildhoodstreptococcalpharyngitis.JAntimicrobChemother1984;14: 261–265.

• WaldE,ReillyJS,BluestoneCD,ChiponisD:Sulbactam/ampicillin in the treatment of acuteepiglottitis in children. Rev Infect Dis 1986; 8:S617–619.

• Daniscovicova-Nogeova A, Galova K,SufliarskaS,KrizanS,KukovaZ,KrupovaI:Ceforoxime-axetil versus ampicillin-sulbactamin therapy of community acquired pneumonia:arandomizedmulticenterstudyin149children.AntiinfectDrugsChemother1999;16: 219–220.

• Solbiati M, Danzi MC, D’Orazio C, Bassetti D:Clinicalevaluationof sulbactam + ampicillininthetreatmentofpediatricurinarytractinfections.Chemioterapia1988;7:393–395.

• Cichocka E, Januszewicz P, Dzierzanowska D:Efficacy of low doses of sultamicillin in urinarytractinfectioninchildren.PediatrPol1993;68:41–45.

• Bohnen JM, Solomkin JS, Dellinger EP, BjornsonHS, Page CP: Guidelines for clinical care: anti-infectiveagentsforintra-abdominalinfection.A Surgical Infection Society policy statement.ArchSurg1992;127:83–89

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Published

2022-06-22

How to Cite

Babita Patial, Poonam Dogra, Sanjay Kumar, Mohit Sharma, & Anil Kumar. (2022). Clinical Efficacy of Hybrid of Ampicillin and Sultamicillin: A Review. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 193–200. Retrieved from https://www.ijrasb.com/index.php/ijrasb/article/view/400

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