Ethnobotanical Study of Medicinal Plants of Kashmir Valley, India Having Anticancer Properties

  • Syed Suhail Hamdani
  • Basharat Ahmad Bhat
  • Showkat Nissar
Keywords: Medicinal properties, Tribes, Phytochemical study, Anticancer agents


Kashmir valley is inhabited by various tribes living in close vicinity of enriched forests. These tribes have always used medicinal plants for the treatment of various diseases by traditional methods. Utilization of medicinal plants is directly linked to their culture and history. There are many tribes and villages that are repositories of indigenous knowledge and practice. With due attention to rapid progress in the phytochemical study of plants, they are becoming popular because of their anticancer effects. Documentation of such knowledge is required in view of day to day disappearing knowledge in the new generations. Therefore, in the present study an attempt has been made to document some locally available plants utilized traditionally by the inhabitants of the valley and are having anticancer properties. These plants are likely to provide effective anticancer agents. The aim of this study is to investigate the effective medicinal plants in the treatment of cancer and study their mechanism of action.


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Singh J. (2002). The biodiversity crisis: a multifaceted review. Current Science, 82(6), 638-647.

Organization WH. (2002). Traditional medicine.

Dan Prospek M, Dar G, Khuroo A. (2013). Floristic diversity in the Kashmir Himalaya: progress, problems and prospects. Sains Malaysiana, 42(10), 1377-1386.

Dar GH, Bhagat R, Khan MA. (2002). Biodiversity of the Kashmir Himalaya. Valley Book House.

Hussian M. (2001). Geography of Jammu & Kashmir Rajesh Publications. New Delhi. pp28.

Stewart B, Wild CP. (2014). World cancer report 2014.

Agarwal N, Majee C, Chakraborthy G. (2012). Natural herbs as anticancer drugs. International Journal of Pharm Tech Research, 4(3), 1142-1153.

Rafieian-Kopaie, M., & Nasri, H. (2015). On the occasion of world cancer day 2015; the possibility of cancer prevention or treatment with antioxidants: The ongoing cancer prevention researches. International Journal of Preventive Medicine, 6(1), 108.

Lachenmayer, A., Alsinet, C., Chang, C. Y., & Llovet, J. M. (2010). Molecular approaches to treatment of hepatocellular carcinoma. Digestive and Liver Disease, 42, S264–S272.

Newman, D. J., & Cragg, G. M. (2007). Natural Products as Sources of New Drugs over the Last 25 Years ⊥. Journal of Natural Products, 70(3), 461–477.

Pandey G, Madhuri S. (2009). Some medicinal plants as natural anticancer agents. Pharmacognosy Reviews, 3(6), 259-263.

Isfahani LD, Monajemi R, Amjad L. (2013). Cytotoxic effects of extract and essential oil leaves of Achillea wilhelmsii C. Koch on colon cancers cells. Exp Anim Biol., 1(3), 1-6.

Uddin, S. J., Grice, I. D., & Tiralongo, E. (2011). Cytotoxic Effects of Bangladeshi Medicinal Plant Extracts. Evidence-Based Complementary and Alternative Medicine, 2011, 1–7.

Sharma H, Parihar L, Parihar P. (2011). Review on cancer and anticancerous properties of some medicinal plants. Journal of Medicinal Plants Research, 5(10), 1818-1835.

Azadbakht M, Morteza-Semnani K, Khansari N. (2003). The essential oils composition of Achillea wilhelmsii C. Koch leaves and flowers. Journal of Medicinal Plants, 2(6), 55-58.

Dokhani S, Cottrell T, Khajeddin J, Mazza G. (2005). Analysis of aroma and phenolic components of selected Achillea species. Plant Foods for Human Nutrition, 60(2), 55-62.

Ariga T, Seki T. (2006). Antithrombotic and anticancer effects of garlic‐derived sulfur compounds: A review. Biofactors, 26(2), 93-103.

Thomson M, Ali M. (2003). Garlic [Allium sativum]: a review of its potential use as an anti-cancer agent. Current Cancer Drug Targets, 3(1), 67-81.

Milner J. (2001). A historical perspective on garlic and cancer. The Journal of Nutrition, 131(3), 1027S-31S.

Bianchini, F., & Vainio, H. (2001). Allium vegetables and organosulfur compounds: Do they help prevent cancer? Environmental Health Perspectives, 109(9), 893–902.

Nakagawa, H. (2001). Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines. Carcinogenesis, 22(6), 891–897.

Čolić, M., Vučević, D., Kilibarda, V., Radičević, N., & Savić, M. (2002). Modulatory effects of garlic extracts on proliferation of T-lymphocytes in vitro stimulated with concanavalin A. Phytomedicine, 9(2), 117–124.

N Ahmed, L Laverick, J Sammons, H Zhang, D J Maslin, & H T Hassan. (2001). Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells. Anticancer Res., 21(5), 3519-3523.

Kaul MK. (1997). Medicinal Plants of Kashmir and Ladakh: Temperate and Cold Arid Himalaya. Indus Publishing Company, NEW DELHI.

Juteau, F., Jerkovic, I., Masotti, V., Milos, M., Mastelic, J., Bessière, J.-M., & Viano, J. (2003). Composition and Antimicrobial Activity of the Essential Oil of Artemisia absinthium from Croatia and France. Planta Medica, 69(2), 158–161.

Kordali, S., Kotan, R., Mavi, A., Cakir, A., Ala, A., & Yildirim, A. (2005). Determination of the Chemical Composition and Antioxidant Activity of the Essential Oil of Artemisia dracunculus and of the Antifungal and Antibacterial Activities of Turkish Artemisia absinthium , A. dracunculus , Artemisia santonicum , and Artemisia spicigera Essential Oils. Journal of Agricultural and Food Chemistry, 53(24), 9452–9458.

Meschler, J. (1999). Thujone Exhibits Low Affinity for Cannabinoid Receptors But Fails to Evoke Cannabimimetic Responses. Pharmacology Biochemistry and Behavior, 62(3), 473–480.

Shafi, G., Hasan, T. N., Syed, N. A., Al-Hazzani, A. A., Alshatwi, A. A., Jyothi, A., & Munshi, A. (2012). Artemisia absinthium (AA): A novel potential complementary and alternative medicine for breast cancer. Molecular Biology Reports, 39(7), 7373–7379.

Gordanian, B., Behbahani, M., Carapetian, J., & Fazilati, M. (2012). Cytotoxic effect of Artemisia absinthium L. grown at two different altitudes on human breast cancer cell line MCF7. Research-in-Medicine, 36(3), 124–131.

Haghi, G., Safaei, A., & Safaei Ghomi, J. (2004). Identification and determination of flavonoids in leaf, dried aqueous and dried hydroalcoholic extract of Artemisia absinthium by HPLC. Iranian Journal of Pharmaceutical Research, Volume 3(Supplement 2).

Akrout, A., Gonzalez, L. A., El Jani, H., & Madrid, P. C. (2011). Antioxidant and antitumor activities of Artemisia campestris and Thymelaea hirsuta from southern Tunisia. Food and Chemical Toxicology, 49(2), 342–347.

Manzoor, J., & Ali, B. (2017). Traditional use of medicinal plants: A report from Pahari community of subdivision Mendhar, District Poonch, Jammu & Kashmir, India. Medicinal Plants - International Journal of Phytomedicines and Related Industries, 9(3), 216.

Andre, C. M., Hausman, J.-F., & Guerriero, G. (2016). Cannabis sativa: The Plant of the Thousand and One Molecules. Frontiers in Plant Science, 7.

Guzmán, M. (2003). Cannabinoids: Potential anticancer agents. Nature Reviews Cancer, 3(10), 745–755.

Velasco, G., Sánchez, C., & Guzmán, M. (2012). Towards the use of cannabinoids as antitumour agents. Nature Reviews Cancer, 12(6), 436–444.

Blázquez, C., González-Feria, L., Álvarez, L., Haro, A., Casanova, M. L., & Guzmán, M. (2004). Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas. Cancer Research, 64(16), 5617–5623.

Pisanti, S., Borselli, C., Oliviero, O., Laezza, C., Gazzerro, P., & Bifulco, M. (2007). Antiangiogenic activity of the endocannabinoid anandamide: Correlation to its tumor-suppressor efficacy. Journal of Cellular Physiology, 211(2), 495–503.

Escribano, J., Alonso, G.-L., Coca-Prados, M., & Fernández, J.-A. (1996). Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Letters, 100(1–2), 23–30.

Abdullaev, F. I., & Frenkel, G. D. (1992). Effect of saffron on cell colony formation and cellular nucleic acid and protein synthesis. BioFactors (Oxford, England), 3(3), 201–204.

Aung, H. H., Wang, C. Z., Ni, M., Fishbein, A., Mehendale, S. R., Xie, J. T., Shoyama, C. Y., & Yuan, C. S. (2007). Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells. Experimental oncology, 29(3), 175–180.

Mousavi, M., Baharara, J., & Asadi-Samani, M. (2014). Anti-angiogenesis effect of crocous sativus L. extract on matrix metalloproteinase gene activities in human breast carcinoma cells. J Herbmed Pharmacol, 3(2), 101–105.

Tavakkol-Afshari, J., Brook, A., & Mousavi, S. H. (2008). Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines. Food and Chemical Toxicology, 46(11), 3443–3447.

Dash B, Kashyap L. (1991). Five Specialized Therapies of Ayurveda, Panchakarma: Based on Ayurveda. Concept Publishing Company, NEW DELHI.

Pan, Y., Wang, X., & Hu, X. (2007). Cytotoxic Withanolides from the Flowers of Datura metel. Journal of Natural Products, 70(7), 1127–1132.

Sasaki, T., Yamazaki, K., Yamori, T., & Endo, T. (2002). Inhibition of proliferation and induction of differentiation of glioma cells with Datura stramonium agglutinin. British Journal of Cancer, 87(8), 918–923.

Li, H., Qing, C., Zhang, Y., & Zhao, Z. (2005). Screening for Endophytic Fungi with Antitumour and Antifungal Activities from Chinese Medicinal Plants. World Journal of Microbiology and Biotechnology, 21(8–9), 1515–1519.

Ahmad IM, Abdalla MY, Mustafa NH, Qnais EY, Abdulla F. (2009). Datura aqueous leaf extract enhances cytotoxicity via metabolic oxidative stress on different human cancer cells. Jordan J Biol Sci., 2(1), 9-14.

Rakashanda S, Ishaq M, Masood A, Amin S. (2012). Antibacterial activity of a trypsin-chymotrypsin-elastase inhibitor isolated from Lavatera cashmeriana camb. seeds. J Anim Plant Sci., 22(4), 983-986.

Syed Rakashanda, Syed Mubashir, Yasrib Qurishi, Abid Hamid, Akbar Masood & Shajrul Amin. (2013). Trypsin inhibitors from Lavatera cashmeriana Camb. seeds: isolation, characterization and in-vitro cytoxicity activity. International Journal of Pharmaceutical Science Invention, 2(5), 55-65.

Gürkök T, Parmaksız İ, Boztepe G, Kaymak E. (2010). Alkaloid biosynthesis Mechanism in Opium Poppy (Papaver somniferum L.). Electronic Journal of BioTechnology, 1(2), 31-45.

Parmaksiz I, ÖZCAN S. (2011). Morphological, chemical, and molecular analyses of Turkish Papaver accessions (Sect. Oxytona). Turkish Journal of Botany, 35(1), 1-16.

Mahmoudian, M., & Rahimi-Moghaddam, P. (2009). The Anti-Cancer Activity of Noscapine: A Review. Recent Patents on Anti-Cancer Drug Discovery, 4(1), 92–97.

Takeuchi R, Hoshijima H, Onuki N, Nagasaka H, Chowdhury Sa, Kawase M, et al. (2005). Effect of anticancer agents on codeinone-induced apoptosis in human cancer cell lines. Anticancer Research, 25(6B), 4037-4041.

Sueoka E, Sueoka N, Kai Y, Okabe S, Suganuma M, Kanematsu K, et al. (1998). Anticancer activity of morphine and its synthetic derivative, KT-90, mediated through apoptosis and inhibition of NF-κB activation. Biochemical and Biophysical Research Communications, 252(3), 566-570.

Zamiri-Akhlaghi A, Rakhshandeh H, Tayarani-Najaran Z, Mousavi SH. (2011). Study of cytotoxic properties of Rosa damascena extract in human cervix carcinoma cell line. Avicenna Journal of Phytomedicine, 1(2), 74-77.

Khatib H, Rezaei-Tavirani M, Keshel SH, Azodi MZ, Omidi R, Biglarian M, et al. (2013). Flow cytometry analysis of Rosa Damascena effects on gastric cancer cell line (MKN45). Iranian Journal of Cancer Prevention, 6, 30-36.

Jung JH, Kim Y, Lee C-O, Kang SS, Park J-H, Im KS. (1998). Cytotoxic constituents of Saussurea lappa. Archives of Pharmacal Research, 21(2), 153-156.

Lee M-G, Lee K-T, Chi S-G, PARK J-H. (2001). Constunolide Induces Apoptosis by ROS-mediated Mitochondrial Permeability Transition and Cytochrome C Release. Biological and Pharmaceutical Bulletin, 24(3), 303-306.

Jeong S-J, Itokawa T, Shibuya M, Kuwano M, Ono M, Higuchi R, et al. (2002). Costunolide, a sesquiterpene lactone from Saussurealappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. Cancer Letters, 187(1-2), 129-133.

Ko S-G, Koh S-H, Jun C-Y, Nam C-G, Bae H-S, Shin M-K. (2004). Induction of apoptosis by Saussurea lappa and Pharbitis nil on AGS gastric cancer cells. Biological and Pharmaceutical Bulletin, 27(10),1604-1610.

Ko SG, Kim H-P, Jin D-H, Bae H-S, Kim SH, Park C-H, et al. (2005). Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells. Cancer Letters, 220(1), 11-19.

Sun C-M, Syu W-J, Don M-J, Lu J-J, Lee G-H. (2003). Cytotoxic sesquiterpene lactones from the root of saussurea l appa. Journal of Natural Products, 66(9), 1175-1180.

Oh G, Pae H, Chung H, Kwon J, Lee J, Kwon T, et al. (2004). Dehydrocostus lactone enhances tumor necrosis factor‐α‐induced apoptosis of human leukemia HL‐60 cells. Immunopharmacology and immunotoxicology, 26(2), 163-175.

Cho JY, Kim AR, Jung JH, Chun T, Rhee MH, Yoo ES. (2004). Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines. European Journal of Pharmacology, 492(2-3), 85-94.

Alsemari, A., Alkhodairy, F., Aldakan, A., Al-Mohanna, M., Bahoush, E., Shinwari, Z., & Alaiya, A. (2014). The selective cytotoxic anti-cancer properties and proteomic analysis of Trigonella Foenum-Graecum. BMC Complementary and Alternative Medicine, 14(1), 114.

Amin A, Alkaabi A, Al‐Falasi S, Daoud SA. (2005). Chemopreventive activities of Trigonella foenum graecum (Fenugreek) against breast cancer. Cell Biology International, 29(8), 687-694.

Durak I, Biri H, Devrim E, Sözen S, Avcı A. (2004). Aqueous extract of Urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer. Cancer Biology & Therapy, 3(9), 855-857.

M Aydin, A Aslaner, A Zengin. (2005). Using urtica dioica in esophageal cancer: A report of a case. The Internet Journal of Surgery, 7(2) 1-3.

Konrad, L., Müller, H.-H., Lenz, C., Laubinger, H., Aumüller, G., & Lichius, J. J. (2000). Antiproliferative Effect on Human Prostate Cancer Cells by a Stinging Nettle Root (Urtica dioica) Extract. Planta Medica, 66(1), 44–47.

Lindholm P, Göransson U, Johansson S, Claeson P, Gullbo J, Larsson R, Bohlin L, & Backlund A. (2002). Cyclotides: A Novel Type of Cytotoxic Agents 1 PL and UG contributed equally to this manuscript. Molecular Cancer Therapeutics, 1(6), 365-369.

Gerlach, S. L., Rathinakumar, R., Chakravarty, G., Göransson, U., Wimley, W. C., Darwin, S. P., & Mondal, D. (2010). Anticancer and chemosensitizing abilities of cycloviolacin O2 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa. Biopolymers, 94(5), 617–625.

Svangård, E., Burman, R., Gunasekera, S., Lövborg, H., Gullbo, J., & Göransson, U. (2007). Mechanism of Action of Cytotoxic Cyclotides: Cycloviolacin O2 Disrupts Lipid Membranes. Journal of Natural Products, 70(4), 643–647.

How to Cite
Syed Suhail Hamdani, Basharat Ahmad Bhat, & Showkat Nissar. (2020). Ethnobotanical Study of Medicinal Plants of Kashmir Valley, India Having Anticancer Properties. International Journal for Research in Applied Sciences and Biotechnology, 7(4), 84-91.

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