In Vivo Histological Study the Potential of Borago officinalis on Spleen and Testis Histo-Architecture on CCL4 Induced Albino Male Mice

  • Marwa A. Kubba Department of Biology, Al-Rasheed University College, Baghdad, IRAQ
Keywords: Borago, medicinal plant, cancer, inflammation and gamma-linolenic acid (GLA)

Abstract

History of medicine and plants dates backside to seclude past when herbal treatment was used and be the only answer to all kind of pain and disease. Nowadays, greater prominence is again to use phytotherapy all over the world. Herbal medicine is a traditional or folk medicine that based on the use of plants’ seeds, berries, roots, leaves, barks, flowers and plant extracts for medicinal purposes. This research study focused the line on the potentail of aqueous and methanolic extract of Borago officinalis (Borago; BO) on spleen and testis of albino male mice alone or after interaction between both plant extracts with CCL4 (toxic compound) in comparison to controls group (negative control; without any treatment and positive control; mice treated with CCL4 only). The results indicated the ability of plant extracts to modulate toxic effect resulted from CCL4 treatment.

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References

Fuemmeler, B.F., Pendzich, M.K. and Tercyak, K.P. (2009). Weight, Dietary, Behavior, and Physical Activity in Childhood and Adolescence: Implications for Adult Cancer Risk. Obese Facts., 2: 179-186.

Toni, I., Flamini, E., Mercatali, L., Sacanna, E., Serra, P. and Amadori, D. (2010). Pathogenesis of osteoblastic bone metastases from prostate cancer. Cancer, 116:1406-1418.

Zemmouri, Hanene, Ammar, Sonda, Boumendjel, Amel, Messarah, Mahfoud, El Feki, Abdelfattah, Bouaziz, Mohamed (2019). Chemical composition and antioxidant activity of Borago officinalis L. leaf extract growing in Algeria, Arabian journal of chemistry,12(8):1954-1963

Colombo, M.L., Assisi, F., Della, Puppa, T., Moro, P., Sesana, F.M., Bissoli,M, et al. (2010). Most commonly plant exposures and intoxications from outdoor toxic plants. J Pharm Sci Res, 2: 417-425.

Zahn, Rumana, Perry, Nicolette, Perry, Elaine, Mukaetova-Ladinska, Elizabeta B (2019). Use of herbal medicines: Pilot survey of UK users’ views Complementary therapies in medicine,44:87-90.

Lim, Tai, Wei, Shimazaki, Naoko, Godo, Yoshihisa, Lim, Yiru (2019). Historical Development and Gentrification of Hokkaido’s Former Coal Mining Areas: Case Studies of Bibai, Kushiro, Mikasa, and Yubari, Coal Mining Communities and Gentrification in Japan ,67-131

Nadir, M. T.; Salih, F. M.; Dhahir, A. J.; Nori, M. and Hussain, A. M. (1986). Antimicrobial activity of Salvia species indigenous to Iraqi. Journal Biological Science Research, 17: 109-117.

Alwachi, S. N. and Husain, D. K. (2014). Research article Tamsulosin hydrochloride (flomax) effects on fertility of albino male mice. International Journal of Recent Scientific Research. 5, 2: 326-331.

Lu, M.F., Xiao, Z.T. and Zhang, H.Y. (2013). Where do health benefits of flavonoids come from? Insights from flavonoid targets and their evolutionary history. Biochem Biophys Res Commun., 434: 701-704.

Zeashan, H., Amresh, G., Singh, S. and Rao, C.V. (2008). Hepatoprotective activity of Amaranthus spinosus in experimental animals. Food Chem Toxicol., 46: 3417-3421.

Aydin, A., Sakrak, O., Yilmaz, T.U. and Kerem, M. (2014). The effects of Hypericum perforatum on hepatic ischemia- -reperfusion injury in rats. Bratisl Lek Listy., 115:209-215.

Yuce, E. and Bagci, E. (2012). The essential oils of the aerial parts of two Hypericum taxa (Hypericum triquetrifolium and Hypericum aviculariifolium subsp. depilatum var. depilatum (Clusiaceae)) from Turkey. Nat Prod Res., 26:1985-1990.

Tanemossu, S.A., Franke, K., Arnold, N., Schmidt, J., Wabo, H.K., Tane, P. and Wessjohann, L.A. (2014). Rare biscoumarin derivatives and flavonoids from Hypericum riparium. Phytochemistry.

Harbige, l.s. and Fisher , B.A. 1 (1997).Effect of omega-6 lipid-rich borage oil feeding on immune function in healthy volunteers. biochem soc trans., 25(2):343S

Yungho ParkIl, O.S.K. and Kang, J. (2019). Synergistic action of Erigeron annuus L. Pers and Borago officinalis L. enhances anti-obesity activity in a mouse model of diet-induced obesity. Nutrition Research, 69:58-66

Ramezani, Mahin, Amiri, Mohammad, S., Zibaee, Elaheh, Boghrati, Zahra, Ayati, Zahra, Sahebkar, Amirhossein, Emami, Seyed A. (2020). A Review on the Phytochemistry, Ethnobotanical Uses and Pharmacology of Borago Species, Current Pharmaceutical ,26(1):110-128

Hafid, R.E.I., Blade, S.F. and Hoyano, S.F.Y. (2002). Seeding date and nitrogen fertilization effects on the performance of borage (Borago officinalis L.) Industrial Crops and Products, 16(3): 193-199.

Published
2021-12-17
How to Cite
Kubba, M. A. (2021). In Vivo Histological Study the Potential of Borago officinalis on Spleen and Testis Histo-Architecture on CCL4 Induced Albino Male Mice. International Journal for Research in Applied Sciences and Biotechnology, 8(6), 79-83. https://doi.org/10.31033/ijrasb.8.6.13