A Review on Understanding the Connecting link between Genes and Cancer and the Involvement of Genetics in Cancer Development

  • Dr Jutishna Bora Amity University
  • Ishani Saha Amity University
Keywords: cancer, cancer genes, tumor cell growth, apoptosis, neoplastic cell, tumor evolution, cancer geneticists

Abstract

Cancer genetics is the scientific discipline that investigates the genes and pathways that drive the development of cancer. Cancer geneticists use several approaches including the analysis of the genomes of cancer patients, and that of their tumors, to identify cancer genes. These studies are performed along with experiments in in vitro and in vivo models to decipher the mechanisms that drive tumorigenesis. Cancer geneticists aim to identify cancer genes, that when mutated, contribute towards cancer development by promoting tumor cell growth and by conferring upon a neoplastic cell the ability to evade the cell cycle and apoptosis checkpoints that might normally control their growth. Cancer geneticists are also interested in the networks and pathways that contribute to tumor development and the way cancer genes work together to market tumor evolution.

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References

Genetics in Prevention and Treatment of Cancer by World Health Organization. https://www.who.int/genomics/about/Cancer.pdf

Lach, R. P., & Adams, D. J. (2013). Cancer Genetics. Brenner’s Encyclopedia of Genetics, 416–419. doi:10.1016/b978-0-12-374984-0.00190-X

Douglas W. Green, Jeffrey A. Drebin, in Surgical Research,2001.

Genetic Testing for Cancer Risk by Cancer.Net. https://www.cancer.net/navigating-cancer-care/cancer- basics/genetics/genetics-cancer

Molecular Tools in Cancer Research. Mauro W. Costa, Nadia Rosenthal, in Abel off’s Clinical Oncology (Fifth Edition),2014

Antoniou AC et al. A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2, and other genes. British Journal of Cancer. 2002. 86(1):76-83.

Bosch FX, de Sanjose S. Chapter 1: Human papillomavirus and cervical cancer—burden and assessment of casualty. J Natl Cancer inst Monogr. 2003, 31:3-13.

Hinds, P. W., & Weinberg, R. A. (1994). Tumor suppressor genes. Current Opinion in Genetics & Development, 4(1), 135–141. doi:10.1016/0959-437x(94)90102-3

Todd R, Wong DT Anticancer Research, 01 Nov 1999, 19(6A):4729-4746; PMID:10697588

The promise of cancer genetics by Dr Daniel A Haber, MD Eric R Fearon, MD Published: May, 1998 DOI: https://doi.org/10.1016/S0140-6736(98)90326-9

Introduction to Cancer Genetics. NHS Greater Glasgow and Clyde; https://www.nhsggc.org.uk/about- us/professional-support-sites/west-of-scotland-genetic-services/cancer-genetics/introduction-to-cancer- genetics/#

The Genetics of cancer by National Cancer Institute (NIC) https://www.cancer.gov/about-cancer/causes- prevention/genetics

Understanding Genetic Testing for Cancer, American Cancer Society https://www.cancer.org/cancer/cancer- causes/genetics.html

Genetic Testing for Inherited Cancer Susceptibility Syndromes; https://www.cancer.gov/about-cancer/causes- prevention/genetics/genetic-testing-fact-sheet

Genetic Testing for Cancer: What to Know; https://www.healthline.com/health/genetic-testing-for-cancer#ideal- candidates

Henry T. Lynch, C. Richard Boland, in Goldman's Cecil Medicine (Twenty Fourth Edition),2012

Knudson, A. G. (2002). Cancer genetics. American Journal of Medical Genetics, 111(1), 96– 102.doi:10.1002/ajmg.10320

Genetics; Jennifer E. Axilbund, Amy L. Gross and Kala Visvanathan in Early Diagnosis and Treatment of Cancer Series: Breast Cancer, 2011

Cancer Genetic Screening and Ethical Considerations for Precision Medicine; R.G. Dumitrescu, in Progress and Challenges in Precision Medicine,2017

Prevention and genetic testing for breast cancer: variations in medical decisions; Louise Bouchard 1, I Blancquaert, F Eisinger, W D Foulkes, G Evans, H Sobol, C Julian-Reynier 2004 Mar;58(6):1085-96. Doi: 10.1016/s0277-9536(03)00263-6.

Published
2021-07-31
How to Cite
Bora, D. J., & Saha, I. (2021). A Review on Understanding the Connecting link between Genes and Cancer and the Involvement of Genetics in Cancer Development. International Journal for Research in Applied Sciences and Biotechnology, 8(4), 62-67. https://doi.org/10.31033/ijrasb.8.4.10
Section
Articles