Phytohormones as Potential Anticancer Agents

  • Ashmit Gill Amity Institute of Biotechnology, Amity University Kolkata, INDIA
  • Somi Patranabis Amity Institute of Biotechnology, Amity University Kolkata, INDIA
Keywords: Cancer, Anticancer agents, Phytohormones, Cancer cell lines, Plant hormones

Abstract

The global burden of cancer is projected to have more than doubled over the next two decades, raising the prospect of a significant investment in health systems, thus posing a real medical problem. The increasing number of people with cancer highlights the need for more cancer prevention efforts. An established history exists for plant-derived compounds as effective anticancer agents. More recently, several phytohormones have been assessed for their ability to inhibit the growth and survival of human cancer cell lines. Phytohormones or plant hormones are chemical messengers responsible for harmonizing various cellular activities that revolves around growth, development, and stress-response. The aim of this literature review article is to present the current state of knowledge concerning the several naturally occurring phytohormones which have shown enormous potential in the prevention and treatment of variety of different type of cancers.

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References

Osborne DJ, McManus MT (2005). Hormones, signals and target cells in plant development. Cambridge University Press. p. 158. ISBN 978-0-521-33076-3.

Classification of auxin related compounds based on similarity of their interaction fields: Extension to a new set of compounds Tomic, S.1,2, Gabdoulline, R.R.1, Kojic-Prodic, B.2 and Wade, R.C.11 European Molecular Biology Laboratory, 69012 Heidelberg, Germany 2Institute Rudjer Boskovic, HR-10000 Zagreb, Croatia.

Walz A, Park S, Slovin JP, Ludwig-Müller J, Momonoki YS, Cohen JD (February 2002). "A gene encoding a protein modified by the phytohormone indoleacetic acid".

Sipes DL, Einset JW (August 1983). "Cytokinin stimulation of abscission in lemon pistil explants". J Plant Growth Regul. 2 (1–3): 73–80. doi:10.1007/BF02042235.

Grennan AK (June 2006). "Gibberellin metabolism enzymes in rice". Plant Physiology. 141 (2): 524–6. doi:10.1104/pp.104.900192. PMC 1475483. PMID 16760495.

Tsai FY, Lin CC, Kao CH (January 1997). "A comparative study of the effects of abscisic acid and methyl jasmonate on seedling growth of rice". Plant Growth Regulation.

Feurtado JA, Ambrose SJ, Cutler AJ, Ross AR, Abrams SR, Kermode AR (February 2004). "Dormancy termination of western white pine (Pinus monticola Dougl. Ex D. Don) seeds is associated with changes in abscisic acid metabolism".

Demole E, Lederer E, Mercier D (1962). "Isolement et détermination de la structure du jasmonate de méthyle, constituant odorant caractéristique de l'essence de jasmin" [Isolation and determination of the structure of methyl jasmonate, a fragrant constituent characteristic of jasmine oil].

Browse J (2005). Jasmonate: an oxylipin signal with many roles in plants. Vitamins and Hormones.

Katsir L, Chung HS, Koo AJ, Howe GA (August 2008). "Jasmonate signaling: a conserved mechanism of hormone sensing". Current Opinion in Plant Biology. 11 (4): 428–35. doi:10.1016/j.pbi.2008.05.004. PMC 2560989. PMID 18583180.

Akiyama K, Matsuzaki K, Hayashi H (June 2005). "Plant sesquiterpenes induce hyphal branching in arbuscular mycorrhizal fungi". Nature. 435 (7043): 824–7. Bibcode:2005Nature. 435..824A. doi:10.1038/nature03608. PMID 15944706.

Gomez-Roldan V, Fermas S, Brewer PB, Puech-Pagès V, Dun EA, Pillot JP, Letisse F, Matusova R, Danoun S, Portais JC, Bouwmeester H, Bécard G, Beveridge CA, Rameau C, Rochange SF (September 2008). "Strigolactone inhibition of shoot branching". Nature.

Saeed W, Naseem S, Ali Z (2017-08-28). "Strigolactones Biosynthesis and Their Role in Abiotic Stress Resilience in Plants: A Critical Review". Frontiers in Plant Science. 8: 1487.

Grove MD, Spencer GF, Rohwedder WK, Mandava N, Worley JF, Warthen JD, et al. (1979). "Brassinolide, a plant growth-promoting steroid isolated from Brassica napus pollen". Nature.

Bennett MJ, Marchant A, May ST and Swarup R: Going the distance with auxin: unravelling the molecular basis of auxin transport. Philos Trans R Soc Lond B Biol Sci 353: 1511-1515, 1998.

Grossmann K: Auxin herbicides: current status of mechanism and mode of action. Pest Manag Sci 66: 113-120, 2010.

Kawano T: Roles of the reactive oxygen species-generating peroxidase reactions in plant defense and growth induction. Plant Cell Rep 21: 829-837, 2003.

Wardman P: Indole-3-acetic acids and horseradish peroxidase: a new prodrug/enzyme combination for targeted cancer therapy. Curr Pharm Des 8: 1363-1374, 2002.

Greco O, Folkes LK, Wardman P, Tozer GM and Dachs GU: Development of a novel enzyme/prodrug combination for gene therapy of cancer: horseradish peroxidase/indole-3-acetic acid. Cancer Gene Ther 7: 1414-1420, 2000.

Park KC, Kim SY and Kim DS: Experimental photodynamic therapy for liver cancer cell-implanted nude mice by an indole3-acetic acid and intense pulsed light combination. Biol Pharm Bull 32: 1609-1613, 2009.

Kim DS, Kim SY, Jeong YM, Jeon SE, Kim MK, Kwon SB, Na JI and Park KC: Light-activated indole-3-acetic acid induces apoptosis in g361 human melanoma cells. Biol Pharm Bull 29: 2404-2409, 2006.

Kim SY, Kim MK, Kwon SB, Na JI, Park KC and Kim DS: Tumor apoptosis by indole-3-acetic acid/light in B16F10 melanoma-implanted nude mice. Arch Dermatol Res 301: 319- 322, 2009.

Su Yeon Kim, Jung Su Ryu, Hailan Li, Woo-Jae Park, Hye-Young Yun, Kwang Jin Baek, Nyoun Soo Kwon, Uy Dong Sohn and Dong-Seok Kim: UVB-Activated Indole-3-Acetic Acid Induces Apoptosis of PC-3 Prostate Cancer Cells. ANTICANCER RESEARCH 30: 4607-4612 (2010)

Chen Huang, Li-Ying Liu, Tu-Sheng Song, Lei Ni, Ling Yang, Xiao-Yan Hu, Jing-Song Hu, Li-Ping Song, Yu Luo, Lu-Sheng Si: Apoptosis of pancreatic cancer BXPC-3 cells induced by indole-3-acetic acid in combination with horseradish peroxidase. World J Gastroenterol. 2005 Aug 7;11(29):4519-23.

C.M. Chen, Cytokinin biosynthesis and interconversion, Physiol. Plant. 101 (1997) 665 – 673

G. Shaw, in: D.W.S. Mok, M.C. Mok (Eds.), Chemistry of Adenine Cytokinins. Cytokinins—Chemistry, Activity and Function, CRC Press, Boca Ranton, FL, 1994, pp. 15 – 34.

Y. Ishii, Y. Hori, S. Sakai, Y. Honma, Control of differentiation and apoptosis of human myeloid leukemia cells by cytokinins and cytokinin nucleosides, plant redifferentiation-inducing hormones, Cell Growth Differ. 13 (2002) 19 – 26.

Ishii, Y., Sakai, S., & Honma, Y. (2003). Cytokinin-induced differentiation of human myeloid leukemia HL-60 cells is associated with the formation of nucleotides, but not with incorporation into DNA or RNA. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1643(1-3), 11–24.

Chen J, Sun Z, Zhang Y, Zeng X, Qing C, Liu J, et al. Synthesis of gibberellin derivatives with anti-tumor bioactivities. Bioorg Med Chem Lett. 2009;19:5496–9.

Zhang Y, Zhang H, Chen J, Zhao H, Zeng X, Zhang H, et al. Antitumor and antiangiogenic effects of GA-13315, a gibberellin derivative. Investig New Drugs. 2012;30:8–16.

Shen S, Tang J. Effects and mechanism of GA-13315 on the proliferation and apoptosis of KB cells in oral cancer. Oncol Lett. 2017;14:1460–3.

Lin Xie , Yajuan Chen, Jingbo Chen, Hongbin Zhang, Yedan Liao, Yonghong Zhou, Ling Zhou and Chen Qing: Anti-tumor effects and mechanism of GA-13315, a novel gibberellin derivative, in human lung adenocarcinoma: an in vitro and in vivo study. Xie et al. Cellular & Molecular Biology Letters (2019) 24:6

Zocchi E, Carpaneto A, Cerrano C, Bavestrello G, Giovine M, Bruzzone S, et al. The temperature signaling cascade in sponges involves a heat-gated cation channel, abscisic acid, and cyclic ADP-ribose. Proc Natl Acad Sci USA 2001;98(26):14859–64.

Zocchi E, Basile G, Cerrano C, Bavestrello G, Giovine M, Bruzzone S, et al. ABAand cADPR-mediated effects on respiration and filtration downstream of the temperature-signaling cascade in sponges. J Cell Sci 2003;116(4):629–36.

Le Page-Degivry MT, Bidard JN, Rouvier E, Bulard C, Lazdunski M. Presence of abscisic acid, a phytohormone, in the mammalian brain. Proc Natl Acad Sci USA 1986;83:1155–8

Livingston V. Abscisic acid tablets and process. US patent no. 3958025; 1976.

Tan H, Lei BL, Li ZD, Zhou JY, Yang J, Zhong J. New use of natural abscisic acid in developing ‘‘differentation inducer’’ drugs of tumor cells. China patent 1,748,674A; 2006.

Hajnoczky G, Davies E, Madesh M. Calcium signaling and apoptosis. Biochem Biophys Res Commun 2003;304(3):445–54.

Parihar A, Parihar MS, Ghafourifar P. Significance of mitochondrial calcium and nitric oxide for apoptosis of human breast cancer cells induced by tamoxifen and etoposide. Int J Mol Med 2008;21(3):317–24.

E. Flescher, Jasmonates in cancer therapy, Cancer Lett. 245 (2007) 1–10.

S. Cohen, E. Flescher, Methyl jasmonate: a plant stress hormone as an anticancer drug, Phytochemistry 70 (2009) 1600–1609

Fingrut O, Flescher E. Plant stress hormones suppress the proliferation and induce apoptosis in human cancer cells. Leukemia 2002; 16:608-16.

Elad Milrot, Anna Jackman, Tatiana Kniazhanski, Pinhas Gonen, Eliezer Flescher , Levana Sherman: Methyl jasmonate reduces the survival of cervical cancer cells and downregulates HPV E6 and E7, and survivin. Cancer Letters 319 (2012) 31-38

Koltai H, Dor E, Hershenhorn J, Daniel M, Weininger S, Lekalla S, Shealtiel H, Bhattacharya C, Eliahu E, Resnick N, Barg R, Kapulnik Y (2010) Strigolactones’ effect on root growth and root-hair elongation may be mediated by auxin-efflux carriers. J Plant Growth Regul 29:129–136

Dor E, Joel DM, Kapulnik Y, Koltai H, Hershenhorn J (2011) The synthetic strigolactone GR24 influences the growth pattern of phytopathogenic fungi. Planta 234:419–427

Bhattacharya C, Bonfante P, Deagostino A, Kapulnik Y, Larini P, Occhiato EG, Prandi C, Venturello P (2009) A new class of conjugated strigolactone analogues with fluorescent properties: synthesis and biological activity. Org Biomol Chem 7:3413–3420

Mwakaboko AS, Zwanenburg B (2011) Single step synthesis of strigolactone analogues from cyclic keto enols, germination stimulants for seeds of parasitic weeds. Bioorg Med Chem 19:5006–5011

C. B. Pollock, H. Koltai, Y. Kapulnik, C. Prandi, R. I. Yarden: Strigolactones: a novel class of phytohormones that inhibit the growth and survival of breast cancer cells and breast cancer stem-like enriched mammosphere cells. Breast Cancer Res Treat (2012) 134:1041–1055

Clouse SD, Sasse JM (1998) Brassinosteroids: essential regulators of plant growth and development. Annu Rev Plant Physiol Plant Mol Biol 49:427–451

Steigerova J, Oklestkova J, Levkova M, Rarova L, Kolar Z, Strnad M (2010) Brassinosteroids cause cell cycle arrest and apoptosis of human breast cancer cells. Chem Biol Interact 188:487–496

J. Malíková, J. Swaczynová, Z. Kolár, M. Strnad, Anticancer and antiproliferative activity of natural brassinosteroids, Phytochemistry 69 (2008) 418–426.

Published
2021-05-20
How to Cite
Ashmit Gill, & Somi Patranabis. (2021). Phytohormones as Potential Anticancer Agents. International Journal for Research in Applied Sciences and Biotechnology, 8(3), 37-43. https://doi.org/10.31033/ijrasb.8.3.7
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Articles