Terminalia arjuna: A Potential Ayurvedic Cardio Tonic

  • Shifali Thakur Shuddhi Ayurveda, Jeena Sikho Lifecare Pvt. Ltd.
  • Hemlata Kaurav Shuddhi Ayurveda, Jeena Sikho Lifecare Pvt. Ltd.
  • Gitika Chaudhary Shuddhi Ayurveda, Jeena Sikho Lifecare Pvt. Ltd.
Keywords: Arjuna, Hritshool, Cardio protective, Arjunone

Abstract

Herbal plants have been a significant source of therapeutic agents to cure human diseases. Plants are being in use for treating various kinds of diseases across the world. Terminalia arjuna is a widely used herbal plant since ancient times. The ancient indian practitioners utilized the powdered tree bark of arjuna for the treatment of "hritshool" (angina) and other cardiovascular problems. Terminalia arjuna is regionally called as arjuna which belongs to the combretaceae family. The plant is utilized as a medicine in the various indigenous system like ayurveda, siddha and unani. Arjunic acid, arjunolic acid, arjungenin, arjunone, arjunolone and luteolin, gallic acid, ellagic acid, oligomeric proanthocyanidins (opcs), phytosterols are the major phytoconstituents of Terminalia arjuna that possesses many useful biological properties like anti-microbial, anti-inflammatory, antioxidant, antifeedant, cardio protective, etc. Various clinical evidence of Terminalia arjuna and its beneficial effects on the cardiovascular system. The present review is summarizing the phytomedicinal value of Terminalia arjuna in ayurveda and the folk system of medicine.

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References

WHO. World Health Organization (2002), Traditional Medicine Strategy Report, Document

Heinrich, M. (2000). Ethnobotany and its role in drug development. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 14(7), 479-488.

Tabuti, J. R., Lye, K. A., & Dhillion, S. S. (2003). Traditional herbal drugs of Bulamogi, Uganda: plants, use and administration. Journal of ethnopharmacology, 88(1), 19-44.

Pieroni, A. N. D. R. E. A. (2001). Evaluation of the cultural significance of wild food botanicals traditionally consumed in Northwestern Tuscany, Italy. J Ethnobiol, 21(1), 89-104.

Kim, H., & Song, M. J. (2013). Ethnomedicinal practices for treating liver disorders of local communities in the southern regions of Korea. Evidence-Based Complementary and Alternative Medicine, 2013..

Upadhyay, B., Singh, K. P., & Kumar, A. (2011). Ethno-veterinary uses and informants consensus factor of medicinal plants of Sariska region, Rajasthan, India. Journal of Ethnopharmacology, 133(1), 14-25.

Stickel F, Schuppan D. (2013) Herbal medicine in the treatment of liver diseases. Dig Liver Dis.39:293e304.

Gopinath, K., Venkatesh, K. S., Ilangovan, R., Sankaranarayanan, K., &Arumugam, A. (2013). Green synthesis of gold nanoparticles from leaf extract of Terminalia arjuna, for the enhanced mitotic cell division and pollen germination activity. Industrial crops and products, 50, 737-742.

Yallappa S, Manjanna J, Sindhe MA, Satyanarayan ND, Pramod SN, Nagaraja K. (2013). Microwave assisted rapid synthesis and biological evaluation of stable copper nanoparticles using T. arjuna bark extract. SpectrochimActa A.110: 108e115.

Edison, T. J. I., &Sethuraman, M. G. (2012). Instant green synthesis of silver nanoparticles using Terminalia chebula fruit extract and evaluation of their catalytic activity on reduction of methylene blue. Process Biochemistry, 47(9), 1351-1357.

Dwivedi, S. (1996). Putative uses of Indian cardiovascular friendly plants in preventive cardiology. Ann Natl Acad Med Sci, 32(3&4), 159-175.

Shatvalekar, S. (1943)Atharva Veda Samhita, 1st ed. Balsad, Maharashtra, India. p. 25.

Chopra, R. N., & Chopra, I. C. (1994). Indigenous drugs of India. Academic publishers.

Miller, A. L. (1998). Botanical influences on cardiovascular disease. Alternative medicine review: a journal of clinical therapeutic, 3(6), 422-431.

Bone, K. (1996). Clinical applications of Ayurvedic and Chinese herbs. Monographs for the Western Herbal Practitioner. Australia: Phytotherapy, 137-41.

Kapoor, L. D. (1990). Handbook of Ayurvedic Medicinal Plants, CRC press. Inc., Boca Ration, Florida, USA..

Dwivedi, S., &Jauhari, R. (1997). Beneficial effects of Terminalia arjuna in coronary artery disease. Indian Heart Journal, 49(5), 507-510.

Rao, B. C. S., Singh, R. H., &Tripathi, K. (2001). Effect of Terminalia arjuna (W&A) on regression of LVH in hypertensives: a clinical study. Journal of Research in Ayurveda and Siddha, 22(3-4), 216-227.

Dwivedi, S., Aggarwal, A., Agarwal, M. P., &Rajpal, S. (2005). Role of Terminalia arjuna in ischaemic mitral regurgitation. International journal of cardiology, 100(3), 507-508.

Bharani, A., Ahirwar, L. K., & Jain, N. (2004). Terminalia arjuna reverses impaired endothelial function in chronic smokers. Indian heart journal, 56(2), 123-128.

Bharani, A., Ganguly, A., & Bhargava, K. D. (1995). Salutary effect of Terminalia arjuna in patients with severe refractory heart failure. International Journal of Cardiology, 49(3), 191-199.

Chopra, R. N., & Ghosh, S. (1929). Terminalia arjuna: its chemistry, pharmacology and therapeutic action. The Indian medical gazette, 64(2), 70.

Caius, J. F., Mhaskar, K. S., & Isaacs, M. (1930). A comparative study of the dried barks of the commoner Indian species of genus Terminalia, Linn. Indian Medical Research Memoirs, (Memoir No. 16), 51-75.

Prasad, S. (1941). Histology of the bark of Terminalia arjuna. Indian Journal of Pharmacology, 3, 114-121.

Adamson, R. S. (1910). Note on the Roots of Terminalia arjuna, Bedd. New Phytologist, 9(3), 150-156.

Chopra, R. N., Chopra, I. C., Handa, K. L., &Kapur, L. D. (1958). Terminalia arjuna W&A (Combretaceae). Indigenous drugs of India. Chopra IC, Handa KL, Kapur LD (eds). 2nd ed. Calcutta, Academic Publishers, 421-24.

Pettit, G. R., Hoard, M. S., Doubek, D. L., Schmidt, J. M., Pettit, R. K., Tackett, L. P., &Chapuis, J. C. (1996). Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae). Journal of ethnopharmacology, 53(2), 57-63.

Gurib-Fakim, A., Gueho, J., &Sewraj-Bissoondoyal, M. (1997). The medicinal plants of Mauritius–part 1. International journal of pharmacognosy, 35(4), 237-254.

Dymock WM, Warden GH,and Hooper D., 1891, Pharmacographica India. Thodkar Spink Company, London.

Ghoshal, L.M. (1909) Terminalia arjuna. Ph.D. thesis, Calcutta University, Calcutta, India

Megaw, J. W. D. (1928). Annual Report of the Calcutta School of Tropical Medicine Institute of Hygiene and the Carmichael Hospital for Tropical Diseases 1927. Annual Report of the Calcutta School of Tropical Medicine Institute of Hygiene and the Carmichael Hospital for Tropical Diseases 1927.

HONDA, T., MURAE, T., TSUYUKI, T., & TAKAHASHI, T. (1976). The structure of arjungenin. A new sapogenin from Terminalia arjuna. Chemical and Pharmaceutical Bulletin, 24(1), 178-180.

Anjaneyulu, A.S.R., Prasad, A.V.R. Chemical examination of roots of Terminalia arjuna (Roxb.) Wight &Arnot. Part I. Characterisation of two new triterpenoid glycosides. Indian Journal of Chemistry. 1982. 21B, 530–53

Ali, A., Kaur, G., Hayat, K., Ali, M., &Ather, M. (2003). A novel naphthanol glycoside from Terminalia arjuna with antioxidant and nitric oxide inhibitory activities. Die Pharmazie, 58(12), 932-934.

Ali, A., Kaur, G., Hamid, H., Abdullah, T., Ali, M., Niwa, M., &Alam, M. S. (2003). Terminoside A, a new triterpene glycoside from the bark of Terminalia arjuna inhibits nitric oxide production in murine macrophages. Journal of Asian natural products research, 5(2), 137-142.

Chouksey, B. K., & Srivastava, S. K. (2001). Antifungal agent from Terminalia arjuna. Indian J Chem. B, 40, 354-6.

SarwarAlam, M., Kaur, G., Ali, A., Hamid, H., Ali, M., & Athar, M. (2008). Two new bioactive oleanane triterpene glycosides from Terminalia arjuna. Natural product research, 22(14), 1279-1288.

Sharma, P. N., Shoeb, A., Kapil, R. S., &Popli, S. P. (1982). ARJUNOLONE-A NEW FLAVONE FROM STEM BARK OF TERMINALIA-ARJUNA. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 21(3), 263-264.

Takahashi, S., Tanaka, H., Hano, Y., Ito, K., Nomura, T., & Shigenobu, K. (1997). Hypotensive effect in rats of hydrophilic extract from Terminalia arjuna containing tannin‐related compounds. Phytotherapy Research: An International Journal Devoted to Medical and Scientific Research on Plants and Plant Products, 11(6), 424-427.

Chaudhari, M., &Mengi, S. (2006). Evaluation of phytoconstituents of Terminalia arjuna for wound healing activity in rats. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 20(9), 799-805..

Dwivedi, S., &Udupa, N. (1989). Terminalia arjuna: pharmacognosy, phytochemistry, pharmacology and clinical use. A review. Fitoterapia, 60(5), 413-420.

Jain, S., Yadav, P. P., Gill, V., Vasudeva, N., &Singla, N. (2009). Terminalia arjuna a sacred medicinal plant: phytochemical and pharmacological profile. Phytochemistry Reviews, 8(2), 491-502.

Muthu, C., Ayyanar, M., Raja, N., &Ignacimuthu, S. (2006). Medicinal plants used by traditional healers in Kancheepuram District of Tamil Nadu, India. Journal of Ethnobiology and ethnomedicine, 2(1), 1-10..

Kritikar KR, Basu BD (1975) Indian medicinal plants Part II, 2nd edition. p 1023.

Khory, R. N. (1887). The Bombay materiamedica and their therapeutics (p. 416). Rániná's Union Press..

Prusti, A. B., &Behera, K. K. (2007). Ethnobotanical exploration of Malkangiri district of Orissa, India. Ethnobotanical Leaflets, 2007(1), 14.

Tripathi, V. K., Singh, B., Tripathi, R. C., Upadhyay, R. K., & Pandey, V. B. (1996). Terminalia arjuna: Its present status (A review). Oriental Journal of Chemistry, 12, 01-16.

Bharti, S. (2021). Agro-climatic zone-based identification of elite Terminalia arjuna accessions concerning to arjunolic acid production. SN Applied Sciences, 3(2), 1-19.

Tyler VM, Premila MS. (2014) Ayurvedic Herbs: A Clinical Guide to the Healing Plants of Traditional Indian Medicine.

Pandey G. (2004) DravyagunaVijnana. ChowkhambaKrishnadasAcademy, Varanasi, Reprint.

Mudgal D. (2004) DravyagunVigyan. Ayurvedic Sanskrit Hindi PustakBhandar.

Sharma PV. (2019)DravyagunVigyan. Chaukambha Bharti Academy, Varanasi, Reprint.

Tewari, N. N. (1991). Some crude drugs: source, substitute and adulterant with special reference to KTM crude drug market. SachitraAyurved, 44(4), 284-290.

Shukla, P., & Pawar, R. M. (2012). OA01. 22. Quality aspect and variability observed in physico-chemical characteristics and mineral content of ayurvedicherbo mineral formulations from Indian market. Ancient Science of Life, 32(Suppl 1), S22.

Sunita, G. (1992). Substitute and adulterant plants. Substitute and adulterant plants.

Uniyal, M. R., & Joshi, G. C. (1993). Historical view of the basic principles of the identification of controversial drugs, problems and suggestions. SachitraAyurved, 45(7), 531-536.

Saraswathy, A. (2001). Adulterants and substitutes in Ayurveda. SachitraAyurved, 54(1), 63-66.

Gupta, A. K., Tandon, N., & Sharma, M. (2005). Quality standards of Indian medicinal plants (Vol. 3). Indian Council of Medical Research.

Thorat, A. K., & Mishra, D. N. Medicinal plants for the treatment of Mūtrakṛcchra in the Bṛhattrayī and MādhavaCikitsā treatises of Āyurveda.

Afaq, S. H. (1999). A comparative introduction of the Unani and Tibetan medical traditions. AyurVijnana, 6, 1-4.

Mitra, S. K., & Kannan, R. (2007). A note on unintentional adulterations in Ayurvedic herbs. Ethnobotanical Leaflets, 2007(1), 3.

More, D. B., &Giradkar, P. S. Herbal Drug Adulteration: A Hindrance to the Development of Ayurveda Medicine.

Purnima, B. M., &Kothiyal, P. (2015). A review article on phytochemistry and pharmacological profiles of Nardostachysjatamansi DC-medicinal herb. J PharmacognPhytochem, 3(5), 102-6.

Saha, A., Pawar, V. M., &Jayaraman, S. (2012). Characterisation of polyphenols in Terminalia arjuna bark extract. Indian journal of pharmaceutical sciences, 74(4), 339.

Gupta, S., Bishnoi, J. P., Kumar, N., Kumar, H., &Nidheesh, T. (2018). Terminalia arjuna (Roxb.) Wight &Arn.: Competent source of bioactive components in functional food and drugs. The Pharma Innovation Journal, 7(3), 223-31.

Sharma, P. C., Yelne, M. B., Dennis, T. J., & Joshi, A. (2005). Database on Medicinal plants used in Ayurveda and Sidha. New Delhi: CCRAS, Dept. of AYUSH, Ministry of Health and Family Welfare, Govt. of India, 1, 265-6.

Biswas, M., Biswas, K., Karan, T. K., Bhattacharya, S., Ghosh, A. K., &Haldar, P. K. (2011). Evaluation of analgesic and anti-inflammatory activities of Terminalia arjuna leaf. Journal of Phytology, 3(1).

Singh, G., Singh, A. T., Abraham, A., Bhat, B., Mukherjee, A., Verma, R., ... & Burman, A. C. (2008). Protective effects of Terminalia arjuna against Doxorubicin-induced cardiotoxicity. Journal of ethnopharmacology, 117(1), 123-129.

Pawar, R. S., &Bhutani, K. K. (2005). Effect of oleanane triterpenoids from Terminalia arjuna—a cardioprotective drug on the process of respiratory oxyburst. Phytomedicine, 12(5), 391-393.

Singh, D. V., Verma, R. K., Gupta, M. M., & Kumar, S. (2002). Quantitative determination of oleane derivatives in Terminalia arjuna by high performance thin layer chromatography. Phytochemical Analysis: An International Journal of Plant Chemical and Biochemical Techniques, 13(4), 207-210.

Sawale, P. D., Pothuraju, R., Abdul Hussain, S., Kumar, A., Kapila, S., &Patil, G. R. (2016). Hypolipidaemic and anti‐oxidative potential of encapsulated herb (Terminalia arjuna) added vanilla chocolate milk in high cholesterol fed rats. Journal of the Science of Food and Agriculture, 96(4), 1380-1385.

Saxena, M., Faridi, U., Mishra, R., Gupta, M. M., Darokar, M. P., Srivastava, S. K., ... &Khanuja, S. P. S. (2007). Cytotoxic agents from Terminalia arjuna. Planta medica, 73(14), 1486-1490.

Seth, S., Dua, P., &Maulik, S. K. (2013). Potential benefits of Terminalia arjuna in cardiovascular disease. J. Preventive Cardiology, 3, 428-32.

HONDA, T., MURAE, T., TSUYUKI, T., & TAKAHASHI, T. (1976). The structure of arjungenin. A new sapogenin from Terminalia arjuna. Chemical and Pharmaceutical Bulletin, 24(1), 178-180.

Sharma, S., &Vishnoi, P. (2017). Screening of Phyto-chemical compounds from hydro-ethanolic and ethanolic leaf and bark extracts of Terminalia arjuna and Syzygiumcumini. Screening, 4(06).

Singh, B., Singh, V. P., Pandey, V. B., &Rücker, G. (1995). A new triterpene glycoside from Terminalia arjuna. Planta medica, 61(6), 576-577.

Bhatia, J., Bhattacharya, S. K., Mahajan, P., &Dwivedi, S. (1998). Effect of Terminalia arjuna on coronary flow—an experimental study. Indian J Pharmacol, 30, 118.

Tiwari, A. K., Gode, J. D., & Dubey, G. P. (1990). Effect of Terminalia arjuna on lipid profiles of rabbits fed hypercholesterolemic diet. International Journal of Crude Drug Research, 28(1), 43-47.

Pathak, S. R., Upadhya, L., & Singh, R. N. (1990). Effect of Terminalia arjuna on lipid profile of rabbit fed hypercholesterolemic diet. International Journal of Crude Drug Research, 28, 48-51.

Ram, A., Lauria, P., Gupta, R., Kumar, P., & Sharma, V. N. (1997). Hypocholesterolaemic effects of Terminalia arjuna tree bark. Journal of Ethnopharmacology, 55(3), 165-169.

Takahashi, S., Tanaka, H., Hano, Y., Ito, K., Nomura, T., & Shigenobu, K. (1997). Hypotensive effect in rats of hydrophilic extract from Terminalia arjuna containing tannin‐related compounds. Phytotherapy Research: An International Journal Devoted to Medical and Scientific Research on Plants and Plant Products, 11(6), 424-427.

Tripathi, V. K., Pandey, V. B., Udupa, K. N., & Ru, G. (1992). Arjunolitin, a triterpene glycoside fromTerminalia arjuna. Phytochemistry, 31(1), 349-351.

Pettit, G. R., Hoard, M. S., Doubek, D. L., Schmidt, J. M., Pettit, R. K., Tackett, L. P., &Chapuis, J. C. (1996). Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae). Journal of ethnopharmacology, 53(2), 57-63.

Scassellati-Sforzolini, G., Villarini, L. M., Moretti, L. M., Marcarelli, L. M., Pasquini, R., Fatigoni, C., ... & Grover, I. S. (1999). Antigenotoxic properties of Terminalia arjuna bark extracts. Journal of environmental pathology, toxicology and oncology: official organ of the International Society for Environmental Toxicology and Cancer, 18(2), 119-125.

Woodman, O. L., & Chan, E. C. (2004). Vascular and anti‐oxidant actions of flavonols and flavones. Clinical and Experimental Pharmacology and Physiology, 31(11), 786-790.

Ghosh, C., Ghatak, S., Biswas, K., & Das, A. P. (2021). Status of tree diversity of the Jaldapara National Park in West Bengal, India. Trees, Forests and People, 3, 100061.

Colabawalla, H. M. (1951). An evaluation of the cardiotonic and other properties of Terminalia arjuna. Indian Heart J, 3, 205-230.

Antani, J. A., Gandhi, S., &Antani, N. J. (1991). Terminalia arjuna in congestive heart failure. J. Assoc. Phys. India, 39, 801.

Chaturvedi, P. N. (1967). A study on the effect of an indigenous drug arjuna (Terminalia arjuna W & A). On arterial thrombosis and ischaemic heart disease[MD thesis (Ayurveda)].

Wahal, P. K. (1991). A preliminary report on the inhibitory effect of Abana on platelet aggregation and adhesiveness in cases of coronary heart disease and hypertension. Probe, 30, 312-315.

Dwivedi, S., Singh, S., Dwivedi, M., Aggarwal (2005) A. Effect of Terminalia arjuna on lipoprotein(a) in patients of coronary artery disease (Abstract). In: Proceedings of the 15th Annual Conference of the Indian Society of Hypertension Abstract Book, UCMS-GTB Hospital, Delhi, India. 12–13 November, p. 65.

Bharani, A., Ganguli, A., Mathur, L. K., Jamra, Y., & Raman, P. G. (2002). Efficacy of Terminalia arjuna in chronic stable angina: a double-blind, placebo-controlled, crossover study comparing Terminalia arjuna with isosorbidemononitrate. Indian Heart Journal, 54(2), 170-175.

Wang, W., Ali, Z., Shen, Y., Li, X. C., & Khan, I. A. (2010). Ursane triterpenoids from the bark of Terminalia arjuna. Fitoterapia, 81(6), 480-484.

Wang, W., Ali, Z., Li, X. C., Shen, Y., & Khan, I. A. (2010). Triterpenoids from two Terminalia species. Planta medica, 76(15), 1751-1754.

Published
2021-04-16
How to Cite
Shifali Thakur, Hemlata Kaurav, & Gitika Chaudhary. (2021). Terminalia arjuna: A Potential Ayurvedic Cardio Tonic. International Journal for Research in Applied Sciences and Biotechnology, 8(2), 227-236. https://doi.org/10.31033/ijrasb.8.2.30
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