A Comparative Study of Iron Oxide Nanoparticles Surface Modified Using Carboxylic Acids

  • Archana S. Research and Development Officer at B-Aegis Life Science and Research Pvt. Ltd.
Keywords: Co-precipitation, Iron oxide nanoparticle, Oleic Acid, Citric Acid, Succinic Acid


In the last decade nanotechnology has greatly developed in many research fields such as engineering, electronic, biological and many others. They can offer several possibilities to design tools, to create new techniques or improve the already existing ones, to discover innovative applications. Nano-science is one of the most important research and development frontiers in modern science. Nanotechnology is now widely used throughout the pharmaceutical industry, medicine, electronics, robotics, and tissue engineering. For biological and biomedical applications, magnetic iron oxide nanoparticles are the primary choice because of their biocompatibility, super-paramagnetic behavior and chemical stability.

The purpose of this work is the design, development and surface modification of magnetic nanoparticles. Naked iron oxide nanoparticles have high chemical activity, toxicity and aggregate in the body fluid therefore providing surface coating for the stability of the magnetic nanoparticles. These protective shells not only stabilize the magnetic iron nanoparticles but also can be used for further functionalization. Here the iron oxide nanoparticles were prepared by co-precipitation method, then this nanoparticle is modified using acids- oleic acid and succinic acid and a comparative study is carried out. The TEM, FTIR and DSC characterization techniques were used to confirm the surface modification. After which, it was found the iron oxide nanoparticle with succinic acid gives a uniform coating of the three and can be used for further functionalization for various applications.


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A.-H. Lu, W. Schmidt, N. Matoussevitch, H. Bönnemann, B. Spliethoff, B. Tesche, E. Bill, W. Kiefer, F. Schüth (August 2004). "Nanoengineering of a Magnetically Separable Hydrogenation Catalyst". Angewandte Chemie International Edition 43 (33): 4303–4306.

A.K. Gupta, M. Gupta (June 2005). "Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications". Biomaterials 26 (18): 3995–4021.

S. Mornet, S. Vasseur, F. Grasset, P. Verveka, G. Goglio, A. Demourgues, J. Portier, E. Pollert, E. Duguet (2006). Prog. Solid State Chem. 34: 237.

B. Gleich, J. Weizenecker (2005). "Tomographic imaging using the nonlinear response of magnetic particles". Nature 435 (7046): 1214–1217• T. Hyeon (2003). Chem. Commun.: 927.

D. W. Elliott, W.-X. Zhang (2001). Environ. Sci. Technol. 35: 4922.

J. Philip, Shima.P.D. B. Raj (2006). "Nanofluid with tunable thermal properties". Applied Physics Letters 92: 043108.

J.Philip, T.J.Kumar, P.Kalyanasundaram, B.Raj (2003). "Tunable Optical Filter". Measurement Science & Technology 14: 1289–1294.

V. Mahendran and J.Philip “Nanofluid based opticalsensor for rapid visual inspection of defects in ferromagnetic materials”Appl. Phys. Lett. 100, 073104(2012);

J.Philip, V. Mahendran, and Leona J. Felicia “A Simple, In-Expensive and UltrasensitiveMagnetic Nanofluid Based Sensor for Detection of Cations, Ethanol and Ammonia ” J. Nanofluids 2, 112-119 (2013)

Teja, Amyn S.; Koh, Pei-Yoong (2009). "Synthesis, properties, and applications of magnetic iron oxide nanoparticles". Progress in Crystal Growth and Characterization of Materials 55: 22.

C. V. Thach, N. H. Hai_ and N. Chau,” Size Controlled Magnetite Nanoparticles and Their Drug Loading Ability “Journal of the Korean Physical Society, ( 2008), 1332-1335,vol 5

Sophie Laurent1, Morteza Mahmoudi, “Superparamagnetic iron oxide nanoparticles: promises for diagnosis and treatment of cancer”Int J Mol Epidemiol Genet 2011;2(4):367-390

Mahnaz Mahdavi , Mansor Bin Ahmad , Md Jelas Haron , Farideh Namvar,Behzad Nadi , Mohamad Zaki Ab Rahman and Jamileh Amin ,” Synthesis, Surface Modification and Characterisation of Biocompatible Magnetic Iron Oxide Nanoparticles for Biomedical Applications” Molecules 2013, 18, 7533-7548

H. Asnaashari Eivari, A. Rahdar, H.Arabi et al (2012),”Preparation of supermagnatic iron oxide nanoparticles and investigating their magnetic properties”Vol 5 131-135

K. Kim, Y. Zhang, W. Voit, K.V. Rao, M. Muhammed(2008)”A simple way to synthesize superparamagnetic iron oxide nanopartilces prepared by co –precipitation technique”Vol 6 543-612

M. Răcuciu, D.E. Creangă, A. Airinei, D. Chicea, V. Bădescu, “Synthesis and properties of magnetic nanoparticles coated with biocompatible compounds”Materials Science-Poland, Vol. 28, No. 3, 2010

Alona Gabrene, Janina Setina, Inna Juhnevica and Gundars Mezinskis, “Stabilization of Magnetite Nanoparticles by Encapsulation into the Silica Matrix”J Chem. Eng. 8 (2014) 42-46

Lind M.J., M.J. (2008). "Principles of cytotoxic chemotherapy". Medicine 36 (1): 19–23.

Nastoupil, LJ; Rose, AC; Flowers, CR (2012). "Diffuse large B-cell lymphoma: current treatment approaches". Oncology (Williston Park, N.Y.) 26 (5): 488–95.

Freedman, A (2012). "Follicular lymphoma: 2012 update on diagnosis and management". American journal of hematology 87 (10): 988–95.

Rampling, R; James, A; Papanastassiou, V (2004). "The present and future management of malignant brain tumours: surgery, radiotherapy, chemotherapy". Journal of neurology, neurosurgery, and psychiatry. 75 Suppl 2 (Suppl 2): ii24–30..

Madan, V; Lear, JT; Szeimies, RM (2010). "Non-melanoma skin cancer". Lancet 375 (9715): 673–85.

CK Bomford, IH Kunkler, J Walter. Walter and Miller’s Textbook of Radiation therapy (6th Ed), p311

Jongnam Park, Jin Joo, Soon Gu Kwon, Youngjin Jang, and Taeghwan Hyeon (2007) J.Chem. “A Mechanism for the adsorption of carboxylic acids onto the surface of magnetic nanoparticles”,Int. Ed. 2007, 46, 4630 – 4660.

S. Ayyappan, G. Gnanaprakash, G. Panneerselvam, M.P. Antony, and John Philip, “Intracellular trafficking of superparamagnetic iron oxide nanoparticles conjugated with TAT peptide: 3-dimensional electron tomography analysis” J. Phys. Chem. C 2008, 112, 18376–18383

Xun Wang, Jing Zhuang, Qing Peng and Yadong Li ,” Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging”Nature, Vol 437, 121-124, 1 September 2005.

María Elisa de Sousa, Marcela Beatriz Fernandez van Raap, Patricia Claudia Rivas, Pedro Mendoza Zélis,Pablo Girardin, Gustavo A. Pasquevich, Jose L. Alessandrini, Diego Muraca, and Francisco H Sánchez “Hybrid magnetic nanostructures (MNS) for magnetic resonance imaging applications”J. Phys. Chem. C,Feb 2013

Maria E. N. P. Ribeiro ,Nágila M. P. S. Ricardo , Tamara Gonçalves , Luigi Carbone , Telma L. G. Lemos ,Otília D. L. Pessoa and Pierre B. A. Fechine , “multimodal spion-creka peptide based agents for molecular imaging of microthrombus in a rat myocardial ischemia-reperfusion model”int. j. mol. sci. 2013, 14, 18269-18283

L. Li , K.Y. Mak, C.W. Leung , K.Y. Chan , W.K. Chan , W. Zhong , P.W.T. Pong , “Engineering of cell penetrating peptides over iron oxide nanopartilces”Microelectronic Engineering 110 (2013) 329–334

K.R.Vinodh, D.Sandhya, D.Banji and T. Rohit Reddy .”Application of iron oxide nanopartilces in tumor targeting and imaging “International Journal of Pharmaceutical Sciences and Nanotechnology,Vol 4,Issue 4 January-March 2012

Sutima Chatrabhuti, Suwabun Chirachanchai, “Surface Functionalization of different polymers and other surfactants on the iron oxide nanopartilces” Carbohydrate Polymers 97 (2013) 441– 450

L. Borlido , A.M. Azevedo , A.C.A. Roque , M.R. Aires-Barros , “Nanoparticle imaging for MRI and NMR researchers” Biotechnology Advances 31 (2013) 1374–1385

Veerle Kersemans and Bart Cornelissen, “ Effect of ligand density,target density and size on the nanoparticle” Pharmaceuticals 2010, 3, 600-620

Maarten Bloemen ,Ward Brullot ,Tai Thien Luong , Nick Geukens , Ann Gils ,Thierry Verbiest, “ Synthesis and applications of iron oxide nanoparticles in biomedical fields”J Nanopart Res (2012) 14:1100N.

Nitin Æ L. E. W. LaConte Æ O. Zurkiya Æ X. Hu, G. Bao, “Effect of the surface ligands and its different applications in different fields” J Biol Inorg Chem (2004) 9: 706–712

How to Cite
Archana S. (2021). A Comparative Study of Iron Oxide Nanoparticles Surface Modified Using Carboxylic Acids. International Journal for Research in Applied Sciences and Biotechnology, 8(1), 116-125. https://doi.org/10.31033/ijrasb.8.1.13