Article Review: Virulence Factors of Coagulase-Negative Staphylococci Isolates from Iraqi Patients

  • Rana H. Raheema
  • Ban H. Qaddoori
  • Marwa A. Al-Asady
Keywords: Coagulase-negative Staphylococci, Virulence factors, Antibiotics resistance

Abstract

The aim objective of this research is a review study of the virulence factors of coagulase-negative staphylococci (Co.N.S) species isolated from Iraqi patients. The world is now facing a major problem between microbes and antibiotics. The most important of these microbes are Co.N.S species and they are one of the opportunistic microorganism and considered one of the causative agent of nosocomial infection, bloodstream infections (especially in neonatal sepsis and catheter-related bloodstream), urinary-tract infections, mastitis, wound infections and ear/eye infection. Where these bacteria are notable by their resistance to various antibiotics by produce β-lactamase, present of efflux-mechanisms pumps, increase thickness of cell well or by horizontal transfer of resistance genes (plasmid) from other bacteria of the same or different species.

The too much use of antibiotics, led to the resistance of microbes to these antibiotics and is the major cause of the current problems of the world, as microbes have the capability to develop mechanisms that allow them to overawed these antibiotics more rapidly and difficult to find choices to these antibiotics.

As well as having an important virulence factor is biofilm (polysaccharide intracellular adhesion) that resists phagocytosis and primarily responsible for chronic infections because of their resistance to phagocytosis and killing due to cellular/ humoral immunity. In addition, having toxin, protease, hemolysins, urease, lipase and catalase help them to colonization/ invading the host tissue and evasion the host immunity.

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References

Abdrabaa, M.K. and Flayyih, M.T. (2019). Autolysis Activity of Vancomycin Resistance Staphylococcus epidermidis. Iraqi Journal of Biotechnology, 18(2):1-20.

Al-Asady, M.A., Makhrmash, J.H., Taqi, A.M. (2020). Comprisal effect of antibiotics and probiotic on coagulase negative staphylococci clinical isolates. plant archives, 20(2); 3002-3009.

Al-Charrakh, A.H. and Obayes, M.H. (2014). First Record of Isolation and Characterization of Methicillin Resistant Staphylococcus lugdunensis from Clinical Samples in Iraq, BioMed Research International, Article ID 736259, 8 pages.

Aldeen, A.E.S. and Meshkoor, K.T. (2017). Variety of the Structures of Staphylococcus Cassette Chromosome Mec in Coagulase- negative Staphylococci and Their Effects on Drug Resistance. Journal of Advances in Medicine and Medical Research, 4(10): 1-11.

AL-Hadithi, H.T., AL-Mearaj, K.I. and AL-Hammdi, M.H. (2006). Vancomycin resistance and biofilm formation among methicillin resistant coagulase negative staphylococci isolated from conjunctivitis. The Medical Journal of Basrah University, 24(1, 2).

Ali, F.A., Hadi, A.A. and Majahid Khalif, M. (2009). Sensitivity of Coagulase negative Staphylococci Isolated from Different Diseases Cases to Antibiotics. Journal of Tikrit science, 14(1).

Al-Kalidy, B.A. and AL-Hasnawi, H.H. (2015). Molecular characterization of coagulase negative staphylococci isolates from clinical and carries specimen. Al-Kufa University Journal for Biology, 7(3): 2311-6544.

Al-Mathkhury, H.J.F., Flaih, M.T. and Al-Ghrairy, Z.K.A. (2008). Pathological study on Staphylococcus xylosus isolation from patents with urinary tract infection. Journal of Al-Nahrain University, 11(2): 123-130.

Al-Mulla, A. F., Al-Khafaji, Z.M. and Al-Kareemy, K.K. (2013). Comparison between methods for detection of biofilm produced by staphylococcus epidermis. International Journal of Biological & Pharmaceutical Research, 4(12): 1010-1014.

Al-Salmani, M.S., Al-Salmani, T.S. and Al-Khataua, K.J. (2015). Linezolid resistance among Staphylococcus haemolyticus isolated in Baghdad city. World Journal of Pharmaceutical Research, 4(10).

Arciola, C.R., Campoccia, D., and Montanaro, L. (2002). Detection of biofilm-forming strains of Staphylococcus epidermidis and S. aureus. Expert Rev. Mol. Diagn, 2, 478-84.

Ardic, N., Sareyyupoglu, B., and Ozyurt, M. (2006). Investigation of aminoglycoside modifying enzyme genes in methicillin-resistant staphylococci. Microbiol.Res, 161 (1):49-54.

Baqer, B.A. and Mahdi, L.H. (2019). Biofilm Formation and Antibiotic Resistance of CoagulaseNegative Staphylococci Isolated from Lactating Women with Mastitis in Baghdad, Iraq. Indian Journal of Public Health Research & Development, 10(10).

Barzani, K.Kh. et al. (2016). Detection of Tetracycline Resistant Gen (tet K, tet M ) in Some Coagulase Negative Staphylococci Isolated From Different Clinical Sources In Erbil City. Journal of University of Anbar for pure science, 1(1).

Chambers, H., and DeLeo, F. (2009). Waves of Resistance: Staphylococcus aureus in the antibiotic era. Nature Reviews Microbiology, 7(9): 629-641.

Ferry, T. et al. (2005). Comparative prevalence of superantigen genes in Staphylococcus aureus isolates causing sepsis with a nd without septic shock. Clin Infect Dis, 41(6):771-777.

Flayyih, M.T. and Abdrabaa, M.K. (2015). Vancomycin resistance in Staphylococcus epidermidis clinical isolation. World Journal of Pharmaceutical Research, 4(12).

Grundmann, H., Aires-de-Sousa, M., and Boyce, J. (2011). Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat. Lancet 2, 368 (9538):874-885.

Heilmann, C. et al. (2003). Identification and characterization of a novel autolysin (Aae) with adhesive properties from S. epidermidis. Microbiol, 149, 2769- 2778.

Herman-Bausier, P. et al. (2015). Staphylococcus aureus Fibronectin-Binding Protein A mediates cell-cell adhesion through low-affinity homophilic bonds. mBio, 6(3).

Hussein, S.N. et al. (2019). Superantigenic Toxin Genes in Some Methicillin Resistant Coagulase Negative Staphylococci. Research J. Pharm. and Tech, 12(9).

Ismail, M. Ch., Ali, F.I. and Mohammed, S.W. (2011). Production of Slime Layer by Staphylococcus epidermidis Isolated From Corneal Infection. Baghdad Science Journal, 8(3).

Larkin, E.A., et al. (2009). Staphylococcus aureus: the toxic presence of pathogen extraordinaire. Med. Chem, 16(30):4003-4019.

Lenart-Boron, A. et al. (2016). Phenotypic and molecular antibiotic resistance determination of airborne coagulase negative Staphylococcus spp. strains from healthcare facilities in Southern Poland. Microb. Drug Resist, 22, 515-522.

Limoli, D.H., Jones, C.J., and Wozniak, D.J. (2015). Bacterial Extracellular Polysaccharides in Biofilm Formation and Function. Microbiol Spectr, 3(3).

Lina, G., Etienne, J., and Vandenesch, F. (2000). Biology and pathogenicity of staphylococci other than Staphylococcus aureus and Staphylococcus epidermidis. In: Gram-positive pathogens. J. Inter. Rood, 31, 55-67.

Michelim, L. et al. (2005). Pathogenic factors and antimicrobial resistance of Staphylococcus epidermidis associated with nosocomial infections occurring in intensive care units. Braz. J. Microbiol, 36(1):17-23.

Morello, J., Mizer, H. and Granato, P. (2006). Laboratory Manual and Workbook in Microbiology Applications to Patient Care. McGraw Hill, Boston.

Nezar, G.S., Mohammed, H.Q. and Al-Mayahee, T.M.H. (2020). Isolation, identification, and genetic study for bacterial infection from non-lactating women with acute mastitis. Drug Invention Today, 14(3).

Nunes, R.S.C. et al. (2016). Identification and molecular phylogeny of coagulase-negative staphylococci isolates from Minas Frescal cheese in southeastern Brazil: Superantigenic toxin production and antibiotic resistance. Journal of Dairy Science, 99(4): 2641-2653.

Obajuluwa, A.F. et al. (2017). Antibiotics susceptibility pattern of coagulase-negative staphylococci isolates from orthopaedic patient. 1. 4-7.

Omran, A.S. and Hussein, A.N. (2019). Molecular investigation of Mecgene Among coagulase negative Staphylococcus isolated from different cases. Journal of Physics: Conf. Series, 1234 (2019) 012074.

Otto, M. (2004). Virulence factors of the coagulase-negative staphylococci. Front Biosci, 9, 841-63.

Park, J.Y. et al. (2011). Detection of classical and newly described staphylococcal superantigen genes in coagulase-negative staphylococci isolated from bovine intramammary infections. Veterinary Microbiology, 147, 149-154.

Qin, L., et al. (2017). Toxin Mediates Sepsis Caused by Methicillin-Resistant Staphylococcus epidermidis. journal.ppat, 1006153.

Reed, R.L. (2007). Antibiotics for MRSA Infections. Inter. J. Health, 21,147-164.

Rogers, K.L., Fey, P.D., and Rupp, M.E. (2011). Coagulase-negative staphylococcal infections. Inf. Dis. Clin. North. Am, 23(1):73-98.

Shaker, D.A. and Lafta, I.J. (2019). Methicillin-Resistant Staphylococcus epidermidis Isolated from Breast Tumors of Iraqi Patients. International Journal of Medical Research & Health Sciences, 7(7): 54-62.

Shrestha, L.B., Bhattarai, N.R., and Khanal, B. (2017). Antibiotic resistance and biofilm formation among coagulase-negative staphylococci isolated from clinical samples at a tertiary care hospital of eastern Nepal. Antimicrobial Resistance and Infection Control, 6 (89).

Sibbald, M.J.J.B. et al. (2012). Mapping the Pathways to Staphylococcal Pathogenesis by Comparative Secretomics. Microbiol. Mol. Biol. Rev, 70(3):755-788.

Singh, S. et al. (2016). Coagulase-negative staphylococci causing blood stream infection at an Indian tertiary care hospital: Prevalence, antimicrobial resistance and molecular characterization. Indian J. Med. Microbiol, (34):500-5.

Solati, S.M. et al. (2015). Prevalence of virulence genes of biofilm producing strains of Staphylococcus epidermidis isolated from clinical samples in Iran. AMB Exper, (5)47.

Taha et al. (2019). Detection of mecA Gene in Methicillin-Resistant Staphylococcus hemolyticus Isolated from Blood Cultures of Neonates in Baghdad. Indian Journal of Public Health Research & Development, 10(9).

Talat, A. et al. (2020). Whole-genome sequence analysis of multidrug-resistant Staphylococcus epidermidis ST35 strain isolated from human ear infection of an Iraqi patient. Journal of Global Antimicrobial Resistance, 21, 318-320.

Published
2020-09-30
How to Cite
Rana H. Raheema, Ban H. Qaddoori, & Marwa A. Al-Asady. (2020). Article Review: Virulence Factors of Coagulase-Negative Staphylococci Isolates from Iraqi Patients. International Journal for Research in Applied Sciences and Biotechnology, 7(5), 363-369. https://doi.org/10.31033/ijrasb.7.5.49