An Overview of DNA Topoisomerase: The Cellular Magicians

  • Riddhimann Mukherjee Final Year B.Tech Student at Bengal Institute of Technology
  • Rupsha Dasgupta Final year B.Tech Student, Bengal Institute of Technology
Keywords: DNA Replication, DNA Topoisomerase, DNA Topology, Drug Targets, Gyrase, Quinolones, Supercoiling, Transcription

Abstract

During any cellular process that involves DNA, a phenomenon might occur in the DNA double helix, which is known as supercoiling. The most common example of supercoiling is during helicase activity in DNA replication and transcription of DNA, which causes both positive and negative supercoiling on the DNA, and changes it’s topology. Any sort of topological change such as supercoiling, imparts stress in the DNA double helix, and can affect the overall activity of DNA. Hence, the topology must be well regulated inside the cell. DNA Topoisomerase is the main enzyme, which regulates the DNA topology in the cell. In this paper, we focus on the types and mechanism of action of DNA Topoisomerase enzymes found in different genera of living organisms, from prokaryotes to higher eukaryotes. Also we have discussed the pharmacological significances of topoisomerase enzymes as potential drug targets.

 

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Author Biographies

Riddhimann Mukherjee, Final Year B.Tech Student at Bengal Institute of Technology
Student of Bio-Technology Department at Bengal Institute of Technology, Kolkata   Done projects on sustaining Ecology and Environment through producing a renewable Carbon dioxide scrubber using algae (2018)
Rupsha Dasgupta, Final year B.Tech Student, Bengal Institute of Technology

Student of Bio-Technology department at Bengal Institute of Technology, Kolkata

Done projects on Biopolymer and Bioelectricity, and submitted an award-winning poster presentation in this aspect in 2018. (State level poster presenting competition by MAKAUT,  rank = 2)

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Published
2020-11-02
How to Cite
Riddhimann Mukherjee, & Rupsha Dasgupta. (2020). An Overview of DNA Topoisomerase: The Cellular Magicians. International Journal for Research in Applied Sciences and Biotechnology, 7(6), 26-30. https://doi.org/10.31033/ijrasb.7.6.5