Isolation and Pharmacological Activities of Curcumin from Curcuma longa L.
Curcuma longa commonly known as turmeric belongs to the family Zingiberaceae. It is mainly used for treating chronic diseases especially Diabetes mellitus. The present study aims at evaluating the anti-oxidant, anti-haemolytic, anti-angiogenesis and anti-bacterial activities of Curcumin fraction. Different antioxidant assays were carried out for evaluating the antioxidant capacity of aqueous extract of Curcuma longa. The maximum1, 1- diphenyl 2-picrylhydrazyl (DPPH) radical scavenging activity of curcumin fraction was 30.62±0.87 % at 60 µg/mL concentration. The inhibitory concentration (IC50) values of DPPH˙ radical scavenging activity was 97.97 µg/mL concentration. The maximum superoxide radical scavenging activity of Curcuma longa extract was 57.01±0.17 % at 60 µg/mL concentration and the inhibitory concentration (IC50) was 46.91 µg/mL concentration. The maximum anti-haemolytic activity of curcumin fraction was 44.53±0.84 and the IC50 was 67.37 µg/mL. The maximum Fe3+ reduction and Mo6+ reduction were 54.85±0.35 % and 61.13±0.21 % at 60 µg/mL concentration and the reduction concentration (RC50) were 51.59 µg/mL and 28.69 µg/mL concentration respectively.
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