Treatment of Alzheimer Disease with Anti-Diabetic Medications

Authors

  • Shrestha Sarkar Department of Pharmacy, Kukreja Institute of Pharmaceutical Sciences, Jhajra, Dehradun, INDIA.
  • Dr. Pooja Mittal Associate Professor, RIMT University, Mandi Gobindgarh, Punjab, INDIA.
  • Vandana Sonaji Amle Masters of Pharmacy, School of Pharmacy, S.R.T.M.U Nanded, INDIA.
  • Dharmaraj Arjun Rathod Masters of Pharmacy, SNIOP, Pusad, INDIA.
  • Akash Samanta Department of Pharmacy, Uttaranchal Institute of Pharmaceutical Sciences, Dehradun, Uttarakhand, INDIA.
  • Vikash Kumar Department of Pharmacy, Uttaranchal Institute of Pharmaceutical Sciences, Dehradun, Uttarakhand, INDIA.

DOI:

https://doi.org/10.31033/ijrasb.9.3.21

Keywords:

Alzheimer's disease, Type 2 DM, Neuro-protective, Insulin dependent

Abstract

AD and T2DM are widespread among elderly globally. Epidemiological studies suggest T2DM causes AD. AD brains have reduced glucose uptake, indicating insulin resistance. A plaques and tau tangles are AD pathology. Insulin resistance in T2DM directly exacerbates A and tau pathologies, while synaptic dysfunction, inflammation, and autophagy impairments are common to both illnesses and indirectly impact A and tau neuronal activity. Understanding how these diseases are linked can help find novel Alzheimer's drug targets.

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Published

2022-06-15

How to Cite

Shrestha Sarkar, Pooja Mittal, Vandana Sonaji Amle, Dharmaraj Arjun Rathod, Akash Samanta, & Vikash Kumar. (2022). Treatment of Alzheimer Disease with Anti-Diabetic Medications. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 123–130. https://doi.org/10.31033/ijrasb.9.3.21

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Vol. 9 No. 3 (2022): May Issue

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